4-Methoxy-4-oxobutanoic acid
4-Methoxy-4-oxobutanoic acid structure
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Common Name | 4-Methoxy-4-oxobutanoic acid | ||
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| CAS Number | 3878-55-5 | Molecular Weight | 132.115 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 259.2±0.0 °C at 760 mmHg | |
| Molecular Formula | C5H8O4 | Melting Point | 54-57 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 104.5±16.1 °C | |
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Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 300(3) , R756-62, (2011) Recent evidence suggests that an acute increase in the generation of phagocyte-like NADPH-oxidase (Nox)-mediated reactive oxygen species (ROS) may be necessary for glucose-stimulated insulin secretion. Using rat islets and INS 832/13 cells, we tested the hypo... |
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Stimulation of insulin release in vivo by the methyl esters of succinic acid and glutamic acid.
Adv. Exp. Med. Biol. 426 , 231-4, (1997)
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Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.
Am. J. Physiol. Endocrinol. Metab. 283(2) , E302-10, (2002) Succinic acid methyl esters are potent insulin secretagogues in rat pancreatic islets, but they do not stimulate insulin release in mouse islets. Unlike rat and human islets, mouse islets lack malic enzyme and, therefore, are unable to form pyruvate from succ... |
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Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.
EMBO J. 16(13) , 3833-41, (1997) In the pancreatic beta-cell, insulin secretion is stimulated by glucose metabolism resulting in membrane potential-dependent elevation of cytosolic Ca2+ ([Ca2+]c). This cascade involves the mitochondrial membrane potential (delta psi[m]) hyperpolarization and... |
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Development of an orthodontic elastic material using EMA-based resin combined with 1-butanol.
Dent. Mater. J. 30(5) , 664-71, (2011) For the development of new orthodontic elastic material, 1-butanol was added to PEMA-TA/HX resin. In the present study, basic experiments to reveal the mechanical properties of the materials were conducted. FT-IR spectroscopy showed that addition of 1-butanol... |
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Fumarate reductase: structural and mechanistic insights from the catalytic reduction of 2-methylfumarate.
FEBS Lett. 580(6) , 1677-80, (2006) The soluble fumarate reductase (FR) from Shewanella frigidimarina can catalyse the reduction of 2-methylfumarate with a k(cat) of 9.0 s(-1) and a K(M) of 32 microM. This produces the chiral molecule 2-methylsuccinate. Here, we present the structure of FR to a... |
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Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.
Biochem. J. 403(1) , 197-205, (2007) The present study was undertaken to determine the main metabolic secretory signals generated by the mitochondrial substrate MeS (methyl succinate) compared with glucose in mouse and rat islets and to understand the differences. Glycolysis and mitochondrial me... |
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Aspartate transport by the Dct system in Rhizobium leguminosarum negatively affects nitrogen-regulated operons.
Microbiology 142 ( Pt 9) , 2603-12, (1996) Amino acid uptake by the general amino acid permease (Aap) of Rhizobium leguminosarum strain 3841 was severely reduced by the presence of aspartate in the growth medium when glucose was the carbon source. The reduction in transport by the Aap appeared to be c... |
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Nutritional value of succinic acid monoethyl ester in starvation.
Ann. Nutr. Metab. 41(2) , 118-25, (1997) Rats were fasted for 48 h, but infused with either NaCl or the sodium salt of monoethyl succinic acid (EMS), both delivered at a rate of 80 mumol/g body weight per day. The infusion of EMS, as compared to NaCl, failed to affect paraovarian adipose tissue or l... |
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Selective loss of glucose-induced amplification of insulin secretion in mouse pancreatic islets pretreated with sulfonylurea in the absence of fuels.
Diabetologia 48(12) , 2563-6, (2005) The beta cell metabolism of glucose, and some other fuels, initiates insulin secretion by closure of ATP-sensitive K+ channels and amplifies the secretory response via unknown metabolic intermediates. The aim of this study was to further characterise the mech... |