Piracetam
Piracetam structure
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Common Name | Piracetam | ||
|---|---|---|---|---|
| CAS Number | 7491-74-9 | Molecular Weight | 142.156 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 337.3±44.0 °C at 760 mmHg | |
| Molecular Formula | C6H10N2O2 | Melting Point | 151-152ºC | |
| MSDS | Chinese USA | Flash Point | 157.8±28.4 °C | |
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Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model.
J. Ethnopharmacol. 159 , 274-84, (2014) Gelsemium sempervirens (L.) J.St.-Hil is a herb used for the treatment of various neuroses in both homeopathic and Ayurvedic systems. The present study examines whether Gelsemium reconstituted tincture can protect against scopolamine induced cognitive discrep... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters.
Acta. Pharm. 64(2) , 223-32, (2014) There are a number of compounds that can modify the activity of ABC (ATP-binding cassette) and SLC (solute carrier) transporters in the blood-brain barrier (BBB). The aim of this study was to investigate the effect of natural and synthetic substances on the e... |
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Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.
J. Med. Chem. 53 , 2197-203, (2010) Glutamate receptors are the most prevalent excitatory neurotransmitter receptors in the vertebrate central nervous system and are important potential drug targets for cognitive enhancement and the treatment of schizophrenia. Allosteric modulators of AMPA rece... |
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Inhibition of excitatory synaptic transmission in hippocampal neurons by levetiracetam involves Zn²⁺-dependent GABA type A receptor-mediated presynaptic modulation.
J. Pharmacol. Exp. Ther. 348(2) , 246-59, (2014) Levetiracetam (LEV) is an antiepileptic drug with a unique but as yet not fully resolved mechanism of action. Therefore, by use of a simplified rat-isolated nerve-bouton preparation, we have investigated how LEV modulates glutamatergic transmission from mossy... |
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Compounds blocking methylglyoxal-induced protein modification and brain endothelial injury.
Arch. Med. Res. 45(8) , 753-64, (2015) Elevated levels of reactive carbonyl species such as methylglyoxal triggers carbonyl stress and activates a series of inflammatory responses leading to accelerated vascular damage. Carbonyl stress is implicated in conditions and diseases like aging, diabetes ... |
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Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
J. Med. Chem. 54 , 2512-6, (2011) A series of cis and trans 3,7-diazabicyclo[4.3.0]nonan-8-ones has been synthesized and tested for their ability to revert scopolamine-induced amnesia in the mouse passive-avoidance test. The racemates of the most potent compounds 4 and 7 were separated and te... |
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Low-content quantification in powders using Raman spectroscopy: a facile chemometric approach to sub 0.1% limits of detection.
Anal. Chem. 87(6) , 3419-28, (2015) A robust and accurate analytical methodology for low-content (<0.1%) quantification in the solid-state using Raman spectroscopy, subsampling, and chemometrics was demonstrated using a piracetam-proline model. The method involved a 5-step process: collection o... |
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Efficacy and safety of pregabalin versus levetiracetam as adjunctive therapy in patients with partial seizures: a randomized, double-blind, noninferiority trial.
Epilepsia 55(7) , 1048-57, (2014) To assess the comparative efficacy and safety of pregabalin and levetiracetam for the reduction of seizure frequency in patients with partial seizures.This was a randomized, double-blind, flexible-dose, parallel-group noninferiority study of pregabalin and le... |
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[Epilepsy in the elderly].
Tidsskr. Nor. Laegeforen. 133(5) , 528-31, (2013) Diagnostic work-up and treatment of patients who have developed epilepsy after the age of 65 can both be difficult. Epilepsy is one of the most common neurological conditions in the elderly, and the incidence of de novo geriatric epilepsy is rising. The aim o... |