Gaboxadol hydrochloride
Gaboxadol hydrochloride structure
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Common Name | Gaboxadol hydrochloride | ||
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| CAS Number | 85118-33-8 | Molecular Weight | 176.601 | |
| Density | N/A | Boiling Point | 295.7ºC at 760 mmHg | |
| Molecular Formula | C6H9ClN2O2 | Melting Point | 236 °C | |
| MSDS | USA | Flash Point | 132.6ºC | |
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Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
J. Neurosci. 34(31) , 10361-78, (2014) The enteric nervous system (ENS) provides the intrinsic neural control of the gastrointestinal tract (GIT) and regulates virtually all GI functions. Altered neuronal activity within the ENS underlies various GI disorders with stress being a key contributing f... |
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Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice.
Psychopharmacol. Ser. 232(8) , 1415-26, (2015) Allopregnanolone (ALLO) is an endogenous neuroactive steroid thought to alter the reinforcement value of alcohol (ethanol) due to its actions as a positive modulator of the GABAA receptor (GABAAR). Extrasynaptic GABAARs may be a particularly sensitive target ... |
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Effects of gaboxadol on the expression of cocaine sensitization in rats.
Exp. Clin. Psychopharmacol. 24 , 131-41, (2016) Behavioral sensitization to psychostimulants is associated with changes in dopamine (DA), glutamate, and GABA within the mesocorticolimbic and nigrostriatal DA systems. Because GABAA receptors are highly expressed within these systems, we examined the role of... |
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Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice.
Exp. Neurol. 277 , 178-89, (2016) Changes in functional GABAAR signaling in hippocampus have previously been evaluated using pre-clinical animal models of either diffuse brain injury or extreme focal brain injury that precludes measurement of cells located ipsilateral to injury. As a result, ... |
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4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
J. Med. Chem. 26 , 895-900, (1983) The thio analogues of the GABA (gamma-aminobutyric acid) agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol), the GABA uptake inhibitor THPO (4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol), and the glycine antagonist THAZ (5,6,7,8-tetrahydro-4H-iso... |
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Chemistry and pharmacology of the GABA agonists THIP (Gaboxadol) and isoguvacine. Krogsgaard-Larsen, et al.
Drugs of the Future 9 , 597-618, (1984)
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Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists.
Sleep 22 , 33, (1999) This paper reviews the sleep effects of systemically administered agonistic modulators of GABAA receptors, including barbiturates, benzodiazepines, zolpidem, zopiclone and neuroactive steroids, and the selective GABAA agonists muscimol and THIP. To assess the... |
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Suppression of Human Liver Cancer Cell Migration and Invasion via the GABAA Receptor.
Cancer Biol. Med. 9 , 90-8, (2013) To investigate the roles of the γ-aminobutyric acid (GABA) in the metastasis of hepatocellular carcinoma (HCC) and to explore the potential of a novel therapeutic approach for the treatment of HCC.The expression levels of GABA receptor subunit genes in variou... |
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The contribution of δ subunit-containing GABAA receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex.
Front. Neural Circuits 7 , 203, (2014) We have made use of the δ subunit-selective allosteric modulator DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl benzamide) to assay the contribution of δ-GABAARs to tonic and phasic conductance changes in the cerebellum, thalamus and neocortex. In ... |