L-Homoserine
L-Homoserine structure
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Common Name | L-Homoserine | ||
|---|---|---|---|---|
| CAS Number | 672-15-1 | Molecular Weight | 119.119 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 368.7±32.0 °C at 760 mmHg | |
| Molecular Formula | C4H9NO3 | Melting Point | 203ºC | |
| MSDS | Chinese USA | Flash Point | 176.8±25.1 °C | |
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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
Nature 457(7231) , 910-4, (2009) Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion an... |
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Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.
J. Chromatogr. A. 562(1-2) , 125-38, (1991) Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte S... |
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Gas Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Determination of Isotopologue and Tandem Mass Isotopomer Fractions of Primary Metabolites for (13)C-Metabolic Flux Analysis.
Anal. Chem. 87 , 11792-802, (2015) For the first time an analytical work flow based on accurate mass gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOFMS) with chemical ionization for analysis providing a comprehensive picture of (13)C distribution along the primary metabo... |
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Determination of glutamate uptake by high performance liquid chromatography (HPLC) in preparations of retinal tissue.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 907 , 1-6, (2012) The present study describes a simple and efficient method utilizing high performance liquid chromatography (HPLC) coupled to fluorescence detection for the determination of kinetic parameters of glutamate uptake in nervous tissue. Retinal tissue obtained from... |
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Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery.
Bioorg. Med. Chem. 16 , 5501-13, (2008) A combination of a literature survey, structure-based virtual screening and synthesis of a small library was performed to identify hits to the potential antimycobacterial drug target, glutamine synthetase. The best inhibitor identified from the literature sur... |
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O-Succinyl-L-homoserine-based C4-chemical production: succinic acid, homoserine lactone, γ-butyrolactone, γ-butyrolactone derivatives, and 1,4-butanediol.
J. Ind. Microbiol. Biotechnol. 41(10) , 1517-24, (2014) There has been a significant global interest to produce bulk chemicals from renewable resources using engineered microorganisms. Large research programs have been launched by academia and industry towards this goal. Particularly, C4 chemicals such as succinic... |
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Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation.
Am. J. Physiol. Cell Physiol. 307(2) , C162-8, (2014) N-acyl-homoserine lactones (AHL) are quorum-sensing molecules in bacteria that play important roles in regulating virulence gene expression in pathogens such as Pseudomonas aeruginosa. The present study compared responses between undifferentiated and differen... |
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Substrate specificity and function of the pheromone receptor AinR in Vibrio fischeri ES114.
J. Bacteriol. 195(22) , 5223-32, (2013) Two distinct but interrelated pheromone-signaling systems, LuxI/LuxR and AinS/AinR, positively control bioluminescence in Vibrio fischeri. Although each system generates an acyl-homoserine lactone (AHL) signal, the protein sequences of LuxI/LuxR and AinS/AinR... |
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Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development.
Chem. Commun. (Camb.) 49(15) , 1515-7, (2013) As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C(12)-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate imm... |
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Cysteine Metabolism and Oxidative Processes in the Rat Liver and Kidney after Acute and Repeated Cocaine Treatment.
PLoS ONE 11 , e0147238, (2016) The role of cocaine in modulating the metabolism of sulfur-containing compounds in the peripheral tissues is poorly understood. In the present study we addressed the question about the effects of acute and repeated (5 days) cocaine (10 mg/kg i.p.) administrat... |