hydroxypyridone
hydroxypyridone structure
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Common Name | hydroxypyridone | ||
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| CAS Number | 16867-04-2 | Molecular Weight | 111.099 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 441.4±25.0 °C at 760 mmHg | |
| Molecular Formula | C5H5NO2 | Melting Point | 245 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 220.8±23.2 °C | |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.
Bioorg. Med. Chem. Lett. 18 , 1567-72, (2008) Bacteria can coordinate community-wide behaviors through quorum sensing, that is, the secretion and sensing of autoinducer (AI) molecules. Bacterial quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, ba... |
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Connection of metallamacrocycles via dynamic covalent chemistry: a versatile method for the synthesis of molecular cages.
J. Am. Chem. Soc. 133(18) , 7106-15, (2011) A modular approach for the synthesis of cage structures is described. Reactions of [(arene)RuCl(2)](2) [arene = p-cymene, 1,3,5-C(6)H(3)Me(3), 1,3,5-C(6)H(3)(i-Pr)(3)] with formyl-substituted 3-hydroxy-2-pyridone ligands provide trinuclear metallamacrocycles ... |
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A novel pathway for nicotine degradation by Aspergillus oryzae 112822 isolated from tobacco leaves.
Res. Microbiol. 161(7) , 626-33, (2010) An efficient nicotine-degrading fungus was isolated from tobacco leaves and identified as Aspergillus oryzae 112822 based on morphological characteristics and sequence analysis of 18S rDNA, 5.8S rDNA and the internal transcribed spacer (5.8S-ITS region). When... |
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Effects of mimosine and 2,3-dihydroxypyridine on fiber shedding in Angora goats.
J. Anim. Sci. 77(5) , 1224-9, (1999) The effects of intravenous infusion of mimosine or 2,3-dihydroxypyridine (2,3-DHP) and the effects of oral dose level of mimosine on fiber shedding in Angora goats were determined. In one experiment, 20 mature Angora wethers (36+/-1.9 kg BW) were infused for ... |
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Solvent effects on the electronic absorption spectra and acid strength of some substituted pyridinols.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 58(2) , 239-47, (2002) The electronic absorption spectra of some substituted pyridinols in organic solvents of different polarities are studied. Also, the solvent effects on the intramolecular charge transfer bands are discussed using various solvent parameters. The acid-base equil... |
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2,3-Dihydroxypyridine-loaded cellulose: a new macromolecular chelator for metal enrichment prior to their determination by atomic absorption spectrometry.
Anal. Bioanal. Chem 377(6) , 1079-86, (2003) New macromolecular chelators have been synthesized, by loading 2,3-dihydroxypyridine (DHP) on cellulose via linkers -NH-CH(2)-CH(2)-NH-SO(2)-C(6)H(4)-N=N- and -SO(2)-C(6)H(4)-N=N-, and characterized by elemental analysis, TGA, IR, and CPMAS (13)C NMR spectra.... |
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Antithyroid effect of 2,3-dihydroxypyridine in vivo and in vitro.
Proc. Soc. Exp. Biol. Med. 170(4) , 431-5, (1982)
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Successful transfer of DHP-degrading bacteria from Hawaiian goats to Australian ruminants to overcome the toxicity of Leucaena.
Aust. Vet. J. 63(8) , 259-62, (1986) Cattle and goats in Australia lack the ability to totally degrade 3-hydroxy-4(1H)-pyridone, also known as 3,4-dihydroxy pyridine (3,4 DHP), the ruminal metabolite of mimosine, a toxic aminoacid present in the leguminous shrub Leucaena leucocephala. Ruminants ... |
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Synthesis and iron sequestration equilibria of novel exocyclic 3-hydroxy-2-pyridinone donor group siderophore mimics.
Inorg. Chem. 49(18) , 8208-21, (2010) The synthesis of a novel class of exocyclic bis- and tris-3,2-hydroxypyridinone (HOPO) chelators built on N(2) and N(3) aza-macrocyclic scaffolds and the thermodynamic solution characterization of their complexes with Fe(III) are described. The chelators for ... |