2,2'-Cyclouridine
2,2'-Cyclouridine structure
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Common Name | 2,2'-Cyclouridine | ||
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| CAS Number | 3736-77-4 | Molecular Weight | 226.186 | |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 456.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C9H10N2O5 | Melting Point | 239-240ºC | |
| MSDS | USA | Flash Point | 229.8±31.5 °C | |
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2,2'-Anhydro-1-(3',5'-di-O-acetyl-β-D-arabinofuranosyl)uracil, a cyclouridine nucleoside with a C4'-endo furanosyl conformation.
Acta Crystallogr. C 69(Pt 3) , 282-4, (2013) 2,2'-Anhydro-1-(3',5'-di-O-acetyl-β-D-arabinofuranosyl)uracil, C13H14N2O7, was obtained by refluxing 2',3'-O-(methoxymethylene)uridine in acetic anhydride. The structure exhibits a nearly perfect C4'-endo ((4)E) conformation. The best four-atom plane of the f... |
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Aldrichimica Acta 20 , 52, (1987)
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Inhibitor properties of some 5-substituted uracil acyclonucleosides, and 2,2'-anhydrouridines versus uridine phosphorylase from E. coli and mammalian sources.
Biochem. Pharmacol. 36(23) , 4125-8, (1987) Two series of 5-substituted uracil N(1)-acyclonucleosides, each with a different acyclic chain, were examined as inhibitors of uridine phosphorylase from rat intestinal mucosa, and several against the enzyme from Ehrlich ascites cells. In addition, several 5-... |
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An efficient synthetic approach to 6,5'-(S)- and 6,5'-(R)-cyclouridine.
Chem. Commun. (Camb.) 48(45) , 5587-9, (2012) Here we present new routes for the efficient syntheses of 6,5'-(S)- and 6,5'-(R)-cyclouridine. The syntheses utilize readily accessible uridine as a starting material. This route to the R diastereomer is significantly more efficient than previous synthetic ef... |
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Isolation, crystallization and preliminary crystallographic analysis of Salmonella typhimurium uridine phosphorylase crystallized with 2,2'-anhydrouridine.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 10) , 852-4, (2007) Uridine phosphorylase (UPh; EC 2.4.2.3) is a member of the pyrimidine nucleoside phosphorylase family of enzymes which catalyzes the phosphorolytic cleavage of the C-N glycoside bond of uridine, with the formation of ribose 1-phosphate and uracil. This enzyme... |