Gonadorelin
Gonadorelin structure
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Common Name | Gonadorelin | ||
|---|---|---|---|---|
| CAS Number | 33515-09-2 | Molecular Weight | 1182.290 | |
| Density | 1.54 | Boiling Point | N/A | |
| Molecular Formula | C55H75N17O13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
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Neurokinin B: a new player in immune/inflammatory stress-mediated suppression of reproduction.
Endocrinology 155(7) , 2346-8, (2014)
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Neurokinin B signaling in the female rat: a novel link between stress and reproduction.
Endocrinology 155(7) , 2589-601, (2014) Acute systemic stress disrupts reproductive function by inhibiting pulsatile gonadotropin secretion. The underlying mechanism involves stress-induced suppression of the GnRH pulse generator, the functional unit of which is considered to be the hypothalamic ar... |
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TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients.
FASEB J. 28(4) , 1924-37, (2014) Neurokinin B (NKB) and its G-protein-coupled receptor, NK3R, have been implicated in the neuroendocrine control of GnRH release; however, little is known about the structure-function relationship of this ligand-receptor pair. Moreover, loss-of-function NK3R m... |
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The kisspeptin-GnRH pathway in human reproductive health and disease.
Hum. Reprod. Update 20(4) , 485-500, (2014) The discovery of kisspeptin as key central regulator of GnRH secretion has led to a new level of understanding of the neuroendocrine regulation of human reproduction. The related discovery of the kisspeptin-neurokinin B-dynorphin (KNDy) pathway in the last de... |
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Specialized subpopulations of kisspeptin neurons communicate with GnRH neurons in female mice.
Endocrinology 156(1) , 32-8, (2015) The neuropeptide kisspeptin is a potent stimulator of GnRH neurons and has been implicated as a major regulator of the hypothalamus-pituitary-gonadal axis. There are mainly two anatomically segregated populations of neurons that express kisspeptin in the fema... |
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Diminished ovarian reserve is the predominant risk factor for gonadotropin-releasing hormone antagonist failure resulting in breakthrough luteinizing hormone surges in in vitro fertilization cycles.
Fertil. Steril. 102(1) , 99-102, (2014) To identify risk factors for breakthrough LH surge despite GnRH antagonist (GnRH-ant) suppression in IVF cycles.Case-control study.Academic medical center.All patients undergoing IVF from August 2004 through July 2012 in whom GnRH-ant pituitary suppression (0... |
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Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo.
Aquat. Toxicol. 155 , 73-83, (2014) The fungicide vinclozolin (VZ) is in use globally and known to disrupt reproductive function in male. The present study tested the hypothesis that VZ disrupts testicular function in goldfish (Carassius auratus) by affecting brain-pituitary-testis axis. Goldfi... |
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Metabolic influences on reproduction: adiponectin attenuates GnRH neuronal activity in female mice.
Endocrinology 155(5) , 1851-63, (2014) Metabolic dysfunctions are often linked to reproductive abnormalities. Adiponectin (ADP), a peripheral hormone secreted by white adipose tissue, is important in energy homeostasis and appetite regulation. GnRH neurons are integral components of the reproducti... |
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Vasoactive intestinal peptide modulation of the steroid-induced LH surge involves kisspeptin signaling in young but not in middle-aged female rats.
Endocrinology 155(6) , 2222-32, (2014) Age-related LH surge dysfunction in middle-aged rats is characterized, in part, by reduced responsiveness to estradiol (E2)-positive feedback and reduced hypothalamic kisspeptin neurotransmission. Vasoactive intestinal peptide (VIP) neurons in the suprachiasm... |
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Basal progesterone level as the main determinant of progesterone elevation on the day of hCG triggering in controlled ovarian stimulation cycles.
Arch. Gynecol. Obstet. 290(1) , 169-76, (2014) Modest increases of serum progesterone at human chorionic gonadotrophin (hCG) administration in controlled ovarian hyperstimulation (COH) cycles have been shown to have a negative impact on pregnancy outcomes. The aim of this study was to identify early predi... |