Safingol
Safingol structure
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Common Name | Safingol | ||
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| CAS Number | 15639-50-6 | Molecular Weight | 301.50800 | |
| Density | 0.927 g/cm3 | Boiling Point | 446.2ºC at 760 mmHg | |
| Molecular Formula | C18H39NO2 | Melting Point | 106.8 - 108.7 °C | |
| MSDS | Chinese USA | Flash Point | 223.7ºC | |
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Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site.
Biochem. J. 461(2) , 213-22, (2014) Lipid-conjugated peptides have advanced the understanding of membrane protein functions and the roles of lipids in the membrane milieu. These lipopeptides modulate various biological systems such as viral fusion. A single function has been suggested for the l... |
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Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells.
Arch. Biochem. Biophys. 526(1) , 60-8, (2012) The role of sphingolipids in clathrin-mediated endocytosis is only poorly understood in mammalian cells. Thus the relationship between sphingolipid de novo synthesis and clathrin-mediated endocytosis of transferrin were studied in L929 fibroblasts and two oth... |
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Terpene alcohols inhibit de novo sphingolipid biosynthesis.
Planta Med. 78(5) , 434-9, (2012) The terpene alcohols geranyllinalool, phytol (diterpene alcohol), and farnesol (sesquiterpene alcohol) were newly found to inhibit sphingolipid de novo biosynthesis in LLC-PK₁ cells (pig kidney epithelial cells). A simple chromatographic bioassay was establis... |
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Individual and combined effects of Salmonella typhimurium lipopolysaccharide and fumonisin B1 in broiler chickens.
Poult. Sci. 91(11) , 2785-91, (2012) The aim of this research was to evaluate the individual and combined effects of Salmonella typhimurium lipopolysaccharide (sLPS) and fumonisin B(1) (FB) on performance, relative weight of liver, biological parameters, and histological evaluation of several ti... |
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Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720.
Birth Defects Res. A Clin. Mol. Teratol. 94(10) , 790-803, (2012) Fumonisin B(1) (FB(1)) is a mycotoxin produced by a common fungal contaminant of corn. Ingestion of FB(1)-contaminated food is associated with increased risk for neural tube defects (NTDs). FB(1) induces NTDs in inbred LM/Bc mice. FB(1) inhibits ceramide synt... |
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Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.
J. Pharmacol. Exp. Ther. 337(3) , 830-7, (2011) The sphingosine kinase (SPK)/sphingosine-1-phosphate (S1P) pathway recently has been associated with a variety of inflammatory-based diseases. The majority of these studies have been performed in vitro. Here, we have addressed the relevance of the SPK/S1P pat... |
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TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620.
Tumour Biol. 34(5) , 2573-81, (2013) Our previous study has demonstrated that tissue factor-factor VIIa (TF/FVIIa) complex promotes the proliferation and migration of colon cancer cell line SW620 through the activation of protease-activated receptor 2 (PAR2). In the current study, the underlying... |
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Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.
Lipids Health Dis. 10 , 150, (2011) Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that regulate lipid and glucose metabolism. PPARα is highly expressed in the liver and controls genes involved in lipid catabolism. We previously reported that synt... |
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Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells.
BMC Cancer 11 , 477, (2011) N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a synthetic retinoid with potent pro-apoptotic activity against several types of cancer, but little is known regarding mechanisms leading to chemoresistance. Ceramide and, more recently, other sphingolipid... |
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Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain.
Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 28(8) , 1055-65, (2011) Fumonisins occur mainly in maize and they produce alterations on sphingolipid metabolism, unbalancing the sphinganine (Sa)/sphingosine (So) ratio. This alteration has been proposed as a biomarker of fumonisin exposure. The objective of this study was to estab... |