2-AMINO-3-[METHYLTHIO]BUTYRIC ACID

2-AMINO-3-[METHYLTHIO]BUTYRIC ACID Structure
2-AMINO-3-[METHYLTHIO]BUTYRIC ACID structure
Common Name 2-AMINO-3-[METHYLTHIO]BUTYRIC ACID
CAS Number 443-80-1 Molecular Weight 149.21100
Density 1.202g/cm3 Boiling Point 280.1ºC at 760 mmHg
Molecular Formula C5H11NO2S Melting Point N/A
MSDS Chinese USA Flash Point 123.2ºC

Validation of isoleucine utilization targets in Plasmodium falciparum.

Proc. Natl. Acad. Sci. U. S. A. 108 , 1627-1632, (2011)

Intraerythrocytic malaria parasites can obtain nearly their entire amino acid requirement by degrading host cell hemoglobin. The sole exception is isoleucine, which is not present in adult human hemoglobin and must be obtained exogenously. We evaluated two co...

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.

ChemBioChem. 12 , 1881-1885, (2011)

Isopenicillin N synthase (IPNS) catalyses the synthesis of isopenicillin N (IPN), the biosynthetic precursor to penicillin and cephalosporin antibiotics. IPNS is a non-heme iron(II) oxidase that mediates the oxidative cyclisation of the tripeptide δ-L-α-amino...

Incorporation of amino acid analogs interferes with the processing of the asparagine-linked oligosaccharide of the MOPC-46B kappa light chain.

J. Biol. Chem. 257 , 9039-9042, (1982)

The incorporation of the leucine analog, beta-hydroxyleucine, or the isoleucine analog, 4-thiaisoleucine, into the MPOC-46B kappa chain interfered with the processing of the oligosaccharide moiety of newly synthesized light chains. Analog-containing chains we...