3-Deazaadenosine
3-Deazaadenosine structure
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Common Name | 3-Deazaadenosine | ||
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| CAS Number | 6736-58-9 | Molecular Weight | 266.253 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 665.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C11H14N4O4 | Melting Point | 228-229ºC | |
| MSDS | USA | Flash Point | 356.4±34.3 °C | |
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Disruption of choline methyl group donation for phosphatidylethanolamine methylation in hepatocarcinoma cells.
J. Biol. Chem. 277(19) , 17217-25, (2002) Despite being widely hypothesized, the actual contribution of choline as a methyl source for phosphatidylethanolamine (PE) methylation has never been demonstrated, mainly due to the inability of conventional methods to distinguish the products from that of th... |
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Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction.
Exp. Mol. Med. 33(4) , 284-92, (2001) 3-Deazaadenosine (DZA), a cellular methylation blocker was reported to induce the caspase-3-like activities-dependent apoptosis in U-937 cells. In this study, we analyzed the activation pathway of the caspase cascade involved in the DZA-induced apoptosis usin... |
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Identification of A-minor tertiary interactions within a bacterial group I intron active site by 3-deazaadenosine interference mapping.
Biochemistry 41(33) , 10426-38, (2002) The A-minor motifs appear to be the most ubiquitous helix packing elements within RNA tertiary structures. These motifs have been identified throughout the ribosome and almost every other tertiary-folded RNA for which structural information is available. Thes... |
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Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: relevance to age-related neurodegeneration.
Neuromolecular Med. 6(2-3) , 93-103, (2004) Folate deprivation induces neurotoxicity that is potentiated by additional nutritional and genetic deficiencies including vitamin E and apolipoprotein E deficiency. These deficiencies collectively induce oxidative damage, cognitive impairment, and compensator... |
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3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice.
Atherosclerosis 202(1) , 103-10, (2009) Atherosclerosis and inflammation/angiogenesis are strongly associated including growth of vasa vasorum (VV) and plaque neovascularization, but a causative role for neovascularization has still not been established. Hence, we investigated the effect of 3-deaza... |
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Protein methylation activates reconstituted ryanodine receptor-ca release channels from coronary artery myocytes.
J. Vasc. Res. 41(3) , 229-40, (2004) Ryanodine receptors (RyR) play an important role in the regulation of intracellular Ca(2+) concentration and in the control of vascular tone. However, the mechanism regulating the activity of RyR is poorly understood. The present study determined whether prot... |
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3-Deazaadenosine analogues of p5'A2'p5'A2'p5'A: synthesis, stereochemistry, and the roles of adenine ring nitrogen-3 in the interaction with RNase L.
Bioorg. Med. Chem. 12(13) , 3637-47, (2004) Sequence-specific 3-deazaadenosine (c(3)A)-substituted analogues of trimeric 2',5'-oligoadenylate, p5'A2'p5'A2'p5'A, were synthesized and evaluated for their ability to activate human RNase L (EC 3.1.2.6) aiming at the elucidation of the nitrogen-3 role in th... |
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The S-adenosyl homocysteine hydrolase inhibitor 3-deaza-adenosine prevents oxidative damage and cognitive impairment following folate and vitamin E deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration.
Neuromolecular Med. 5(2) , 171-80, (2004) Deficiencies in folate promote neurodegeneration and potentiate the influence of other risk factors for neurodegeneration. This is accomplished at least in part by increasing levels of the neurotoxin homocysteine (HC). The S-adenosyl homocysteine (SAH) hydrol... |
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Relationship of impairment induced by intracellular S-adenosylhomocysteine accumulation with DNA methylation in human umbilical vein endothelial cells treated with 3-deazaadenosine.
Int. J. Exp. Pathol. 90(6) , 638-48, (2009) The aim of this study was to estimate the relationship of endothelial dysfunction induced by intracellular S-adenosylhomocysteine (SAH) accumulation and DNA methylation in human umbilical vein endothelial cells (HUVEC). The isolated HUVEC were incubated with ... |
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Extended storage of whole blood with 3-deazaadenosine for homocysteine assay.
Ann. Clin. Biochem. 44(Pt 4) , 388-90, (2007) To assess the effectiveness of using 3-deazaadenosine (3DAA) to maintain plasma homocysteine concentrations (tHCy) in whole blood samples.Blood was obtained from five volunteers and samples were maintained at room temperature, in cold packs or in a fridge (0-... |