Lumefantrine
Lumefantrine structure
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Common Name | Lumefantrine | ||
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| CAS Number | 82186-77-4 | Molecular Weight | 528.940 | |
| Density | 1.252 | Boiling Point | 642.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C30H32Cl3NO | Melting Point | 129-131ºC | |
| MSDS | Chinese USA | Flash Point | 342.3±31.5 °C | |
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Antibody and T-cell responses associated with experimental human malaria infection or vaccination show limited relationships.
Immunology 145(1) , 71-81, (2015) This study examined specific antibody and T-cell responses associated with experimental malaria infection or malaria vaccination, in malaria-naive human volunteers within phase I/IIa vaccine trials, with a view to investigating inter-relationships between the... |
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Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity.
Malaria Journal 13 , 359, (2014) Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolism, and excretion. ATP binding cassette (ABC) transport prot... |
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Comparison between Flow Cytometry, Microscopy, and Lactate Dehydrogenase-Based Enzyme-Linked Immunosorbent Assay for Plasmodium falciparum Drug Susceptibility Testing under Field Conditions.
J. Clin. Microbiol. 53 , 3296-303, (2015) Flow cytometry is an objective method for conducting in vitro antimalarial sensitivity assays with increasing potential for application in field sites. We examined in vitro susceptibility to seven anti-malarial drugs for 40 fresh P. falciparum field isolates ... |
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Ex vivo anti-malarial drug susceptibility of Plasmodium falciparum isolates from pregnant women in an area of highly seasonal transmission in Burkina Faso.
Malaria Journal 14 , 251, (2015) Ex vivo assays are usually carried out on parasite isolates collected from patients with uncomplicated Plasmodium falciparum malaria, from which pregnant women are usually excluded as they are often asymptomatic and with relatively low parasite densities. Nev... |
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Pharmacokinetic profile of artemisinin derivatives and companion drugs used in artemisinin-based combination therapies for the treatment of Plasmodium falciparum malaria in children.
Clin. Pharmacokinet. 52(3) , 153-67, (2013) Malaria is one of the most common parasitic infections worldwide. Plasmodium falciparum is the most prevalent strain in Africa and also the most fatal. The disease especially affects children, with those under age 5 years accounting for approximately 86 % of ... |
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Artemether-lumefantrine co-administration with antiretrovirals: population pharmacokinetics and dosing implications.
Br. J. Clin. Pharmacol. 79(4) , 636-49, (2015) Drug-drug interactions between antimalarial and antiretroviral drugs may influence antimalarial treatment outcomes. The aim of this study was to investigate the potential drug-drug interactions between the antimalarial drugs, lumefantrine, artemether and thei... |
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Ebola in Freetown area, Sierra Leone--a case study of 581 patients.
N. Engl. J. Med. 372(6) , 587-8, (2015) Ebola virus continues to cause considerable disease in West Africa, with an initial 70% associated mortality. This report shows improving survival at one center in Sierra Leone. To the Editor: Schieffelin et al. (Nov. 27 issue)1 reported on 106 patients with ... |
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Piperaquine and Lumefantrine resistance in Plasmodium berghei ANKA associated with increased expression of Ca2+/H+ antiporter and glutathione associated enzymes.
Exp. Parasitol. 147 , 23-32, (2014) We investigated the mechanisms of resistance of two antimalarial drugs piperaquine (PQ) and lumefantrine (LM) using the rodent parasite Plasmodium berghei as a surrogate of the human parasite, Plasmodium falciparum. We analyzed the whole coding sequence of Pl... |
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Influence of coadministration of artemether and lumefantrine on selected plasma biochemical and erythrocyte oxidative stress indices in female Wistar rats.
Hum. Exp. Toxicol. 32(2) , 206-15, (2013) Among the artemisinin-based combination therapy (ACT) regimens, artemisinin derivative, artemether in combination with lumefantrine (artemether-lumefantrine, AL) has achieved excellent results in the fight against malarial scourge. In this study, we evaluated... |
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A fast and reliable reversed phase high performance liquid chromatography method for simultaneous determination of selected anti-retroviral and lumefantrine in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 919-920 , 52-60, (2013) A fast and reliable high performance liquid chromatography (HPLC) method with UV diode array detection for simultaneous quantitative analysis of the anti-retroviral drugs, nevirapine (NVP) and efavirenz (EFV) and the anti-malarial, lumefantrine (LUM) in human... |