D-serine
D-serine structure
|
Common Name | D-serine | ||
|---|---|---|---|---|
| CAS Number | 312-84-5 | Molecular Weight | 105.093 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 394.8±32.0 °C at 760 mmHg | |
| Molecular Formula | C3H7NO3 | Melting Point | 220 °C | |
| MSDS | Chinese USA | Flash Point | 192.6±25.1 °C | |
|
Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress.
Oncotarget 6 , 13072-87, (2015) The therapeutic efficacy of nucleoside analogues, e.g. gemcitabine, against cancer cells can be augmented by inhibitors of checkpoint kinases, including Wee1, ATR, and Chk1. We have compared the chemosensitizing effect of these inhibitors in cells derived fro... |
|
|
Angiotensin II activates the RhoA exchange factor Arhgef1 in humans.
Hypertension 65 , 1273-8, (2015) Although a causative role for RhoA-Rho kinase has been recognized in the development of human hypertension, the molecular mechanism(s) and the RhoA guanine exchange factor(s) responsible for the overactivation of RhoA remain unknown. Arhgef1 was identified as... |
|
|
Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2.
Oncotarget 6(6) , 4286-98, (2015) Current knowledge indicates that the mammalian target of rapamycin (mTOR) functions as two complexes, mTORC1 and mTORC2, regulating cell growth, proliferation, survival, differentiation, and motility. Recently mSin1 has been identified as a critical component... |
|
|
Replication stress activates DNA repair synthesis in mitosis.
Nature 528 , 286-90, (2015) Oncogene-induced DNA replication stress has been implicated as a driver of tumorigenesis. Many chromosomal rearrangements characteristic of human cancers originate from specific regions of the genome called common fragile sites (CFSs). CFSs are difficult-to-r... |
|
|
Measles Virus Infection Inactivates Cellular Protein Phosphatase 5 with Consequent Suppression of Sp1 and c-Myc Activities.
J. Virol. 89 , 9709-18, (2015) Measles virus (MeV) causes several unique syndromes, including transient immunosuppression. To clarify the cellular responses to MeV infection, we previously analyzed a MeV-infected epithelial cell line and a lymphoid cell line by microarray and showed that t... |
|
|
A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors.
J. Biol. Chem. 290 , 14107-19, (2015) Anchoring proteins direct protein kinases and phosphoprotein phosphatases toward selected substrates to control the efficacy, context, and duration of neuronal phosphorylation events. The A-kinase anchoring protein AKAP79/150 interacts with protein kinase A (... |
|
|
Modulation of nociceptive dural input to the trigeminocervical complex through GluK1 kainate receptors.
Pain 156(3) , 439-50, (2015) Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) ar... |
|
|
Detection of the staphylococcal enterotoxin D-like gene from staphylococcal food poisoning isolates over the last two decades in Tokyo.
J. Vet. Med. Sci. 77 , 905-11, (2015) The plasmid is a very well-known mobile genetic element that participates in the acquisition of virulence genes, such as staphylococcal enterotoxins (SEs), via horizontal transfer. SEs are emetic toxins and causative agents in staphylococcal food poisoning (S... |
|
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
|
|
Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
Behav. Brain Res. 278 , 186-92, (2015) Glutamatergic dysfunction, particularly the hypofunction of N-methyl-D-aspartate (NMDA) receptors, is involved in the pathophysiology of schizophrenia. The positive modulation of the glycine site on the NMDA receptor has been proposed as a novel therapeutic a... |