1,3-INDANDIONE
1,3-INDANDIONE structure
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Common Name | 1,3-INDANDIONE | ||
|---|---|---|---|---|
| CAS Number | 606-23-5 | Molecular Weight | 146.143 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 302.5±22.0 °C at 760 mmHg | |
| Molecular Formula | C9H6O2 | Melting Point | 129-132 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 113.0±19.3 °C | |
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Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening.
Bioorg. Med. Chem. 16 , 5881-9, (2008) Trihydroxynaphthalene reductase (3HNR) is an essential enzyme in the biosynthesis of fungal melanin and it represents an emerging target for the development of new fungicides and antimicotics. To promote the discovery of new inhibitors, an improved chemical s... |
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Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
J. Med. Chem. 50 , 1876-85, (2007) Carboxylesterases (CE) are ubiquitous enzymes thought to be responsible for the metabolism and detoxification of xenobiotics. Numerous clinically used drugs including Demerol, lidocaine, capecitabine, and CPT-11 are hydrolyzed by these enzymes. Hence, the ide... |
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The mobility of troponin C and troponin I in muscle.
J. Mol. Recognit. 10(4) , 194-201, (1997) In vertebrate skeletal muscle, contraction is initiated by the elevation of the intracellular Ca2+ concentration. The binding of Ca2+ to TnC induces a series of conformational changes which ultimately release the inhibition of the actomyosin ATPase activity b... |
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Dynamic aspects of the incorporation of proteins into biological membranes.
J. Mol. Recognit. 10(4) , 188-93, (1997) The contributions of intramembranous and extramembranous segments of transmembrane proteins to frictional forces have been studied by covalently attached 14N- and 15N-indane dione and maleimide spin labels using saturation transfer electron spin resonance spe... |
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Inhibition by diacylmethane derivatives of mutagenicity in Salmonella typhimurium and tRNA-binding of chemical carcinogens.
Mutat. Res. 262(3) , 189-93, (1991) Effects of diacylmethanes on the mutagenicity of 2-naphthohydroxamic acid, methylnitrosourea, benzo[a]pyrene and aflatoxin B1 in S. typhimurium and the tRNA binding by benzo[a]pyrene and aflatoxin B1 were investigated. Acetylacetone, benzoylacetone and dibenz... |
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Inhibition by diacylmethane derivatives of mutagenicity and nucleic acid binding of 2-aminofluorene derivatives.
J. Natl. Cancer Inst. 81(22) , 1743-7, (1989) The active methylene compounds acetylacetone, 1,1,1-trifluoroacetylacetone, benzoylacetone, dibenzoylmethane, and 1,3-indandione inhibited the mutagenicity of 2-nitrofluorene in Salmonella typhimurium. They also inhibited the N,O-acetyltransferase-catalyzed t... |
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[Effect of anticoagulants of the 4-hydroxycoumarin derivative group on aminotransferase activity in vitro and in vivo].
Folia Med. Cracov. 22(3-4) , 331-9, (1980)
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[Reaction products of indandione with ethyl alpha-cyano-beta-acrylates].
Boll. Soc. Ital. Biol. Sper. 60(1) , 79-84, (1984) In order to obtain biologically active compounds with a probable anticoagulant activity, some new products, by Michael method from indandione and 2-phenylindandione with ethyl alpha-cyano-beta-aryl-acrylates, have been prepared. The reaction of phenylindandio... |
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Diphacinone-induced coagulopathy in the dog.
J. Am. Vet. Med. Assoc. 188(4) , 402-5, (1986) Five cases of coagulopathy caused by consumption of indanedione (diphacinone)-based rodenticides are reported. In each case, acute onset of lethargy and respiratory distress were the predominant initial clinical signs. Thoracic radiography revealed pulmonary ... |
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A diversity-oriented synthesis of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities via microwave-assisted multi-component reactions.
Mol. Divers. 15(2) , 497-505, (2011) Six new series of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities were synthesized by the three-component reactions of aromatic aldehydes, 5-aminoindazole, and various cyclic 1,3-dicarbonyl compounds under microwave irradiation. This protoco... |