4-(Hydroxymethyl)phenoxyacetic acid

4-(Hydroxymethyl)phenoxyacetic acid Structure
4-(Hydroxymethyl)phenoxyacetic acid structure
Common Name 4-(Hydroxymethyl)phenoxyacetic acid
CAS Number 68858-21-9 Molecular Weight 182.173
Density 1.3±0.1 g/cm3 Boiling Point 378.3±22.0 °C at 760 mmHg
Molecular Formula C9H10O4 Melting Point 112-114 °C
MSDS Chinese USA Flash Point 156.3±15.8 °C

Acid-labile resin linkage agents for use in solid phase peptide synthesis.

Int. J. Pept. Protein Res. 20(5) , 451-4, (1982)

Details are given of the preparation of two acid-labile peptide-resin linkage agents for use in solid phase peptide synthesis, viz. 4-hydroxymethylphenoxy-acetic acid and 3-methoxy-4-hydroxymethylphenoxyacetic acid. The latter is suitable for the preparation ...

Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports.

J. Pept. Sci. 6(10) , 534-8, (2000)

A replacement of the acetic acid moiety by valeric acid within the 4-hydroxymethylphenoxyacetic acid (HMP) linker (Sheppard RC, Williams BJ. Acid-labile resin linkage agents for use in solid phase peptide synthesis. Int. J. Peptide Protein Res. 1982; 20: 451-...

E. Atherton et al.

J. Chem. Soc. Chem. Commun. , 537, (1978)

J. Chem. Soc. Chem. Commun. , 539, (1978)

A. Dryland, R.C. Sheppard

J. Chem. Soc. Perkin Trans. I , 125, (1986)