Dimethyl 2-oxopentanedioate
Dimethyl 2-oxopentanedioate structure
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Common Name | Dimethyl 2-oxopentanedioate | ||
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| CAS Number | 13192-04-6 | Molecular Weight | 174.151 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 249.4±23.0 °C at 760 mmHg | |
| Molecular Formula | C7H10O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 105.0±22.7 °C | |
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Deficiencies in Cellular Processes Modulated by the Retinoblastoma Protein Do Not Account for Reduced Human Cytomegalovirus Replication in Its Absence.
J. Virol. 89 , 11965-74, (2015) Despite encoding multiple viral proteins that modulate the retinoblastoma (Rb) protein in a manner classically defined as inactivation, human cytomegalovirus (HCMV) requires the presence of the Rb protein to replicate efficiently. In uninfected cells, Rb cont... |
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Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.
PLoS ONE 9(12) , e115144, (2014) Recent work has highlighted glutaminase (GLS) as a key player in cancer cell metabolism, providing glutamine-derived carbon and nitrogen to pathways that support proliferation. There is significant interest in targeting GLS for cancer therapy, although the ge... |
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Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation.
Stem Cells 33 , 2613-27, (2015) Autologous transplantation of cardiac progenitor cells (CPCs) alleviates myocardial dysfunction in the damaged heart; however, the mechanisms that contribute to their reparative qualities remain poorly understood. In this study, we examined CPC metabolism to ... |
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Electrochemical behaviour of dimethyl-2-oxoglutarate on glassy carbon electrode.
Bioelectrochemistry 77(2) , 145-50, (2010) The electrochemical behaviour of dimethyl-2-oxoglutarate (MOG), a key intermediate in the Krebs cycle and an important nitrogen transporter in the metabolic pathways in biological processes, was investigated by cyclic voltammetry, square wave voltammetry and ... |
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A novel PNA-monomer for recognition of thymine in triple-helix structures.
Nucleosides Nucleotides Nucleic Acids 22(5-8) , 1331-3, (2003) To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synth... |
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Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.
PLoS ONE 9(11) , e113865, (2014) Hypoxia-inducible factor 1α (HIF-1α), a major mediator of tumor physiology, is activated during tumor progression, and its abundance is correlated with therapeutic resistance in a broad range of solid tumors. The accumulation of HIF-1α is mainly caused by hyp... |
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Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.
Mol. Syst. Biol. 7 , 523, (2011) Oncogenes such as K-ras mediate cellular and metabolic transformation during tumorigenesis. To analyze K-Ras-dependent metabolic alterations, we employed ¹³C metabolic flux analysis (MFA), non-targeted tracer fate detection (NTFD) of ¹⁵N-labeled glutamine, an... |
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Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.
EMBO J. 33(12) , 1365-82, (2014) Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. Hypoxia-inducible factor 1A (HIF1A) is a major regula... |
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An efficient synthesis of 4-aryl kainic acid analogs. Maeda H, et al.
Tetrahedron 55(4) , 943-54, (1999)
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