DELAVIRDINE MESYLATE
DELAVIRDINE MESYLATE structure
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Common Name | DELAVIRDINE MESYLATE | ||
|---|---|---|---|---|
| CAS Number | 147221-93-0 | Molecular Weight | 552.667 | |
| Density | N/A | Boiling Point | 732ºC at 760mmHg | |
| Molecular Formula | C23H32N6O6S2 | Melting Point | 118-120ºC | |
| MSDS | Chinese USA | Flash Point | 396.5ºC | |
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Colloid formation by drugs in simulated intestinal fluid.
J. Med. Chem. 53 , 4259-65, (2010) Many organic molecules form colloidal aggregates in aqueous solution at micromolar concentrations. These aggregates promiscuously inhibit soluble proteins and are a major source of false positives in high-throughput screening. Several drugs also form colloida... |
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Methylmethacrylate–sulfopropylmethacrylate nanoparticles with surface RMP-7 for targeting delivery of antiretroviral drugs across the blood–brain barrier
Colloids Surf. B Biointerfaces 90 , 75-82, (2012) Graphical abstract |
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Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.
Bioorg. Med. Chem. 21(7) , 2128-34, (2013) In continuation of our efforts toward identification and optimization of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs), we have employed a structure-based bioisosterism strategy, with which a new series of diarylpyridazine (DAPD) derivatives ... |
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Solid lipid nanoparticles comprising internal Compritol 888 ATO, tripalmitin and cacao butter for encapsulating and releasing stavudine, delavirdine and saquinavir.
Colloids Surf. B Biointerfaces 88(2) , 682-90, (2011) Solid lipid nanoparticles (SLNs) with complex internal phase were fabricated for formulating stavudine (D4T), delavirdine (DLV), and saquinavir (SQV). The lipids including Compritol 888 ATO, tripalmitin, and cacao butter were stabilized by L-α-phospatidylchol... |
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Modifying the diffusion layer of soluble salts of poorly soluble basic drugs to improve dissolution performance.
Mol. Pharm. 7(5) , 1441-9, (2010) The dissolution mechanism of soluble salts of poorly soluble bases can be complex because both the dissolution of the salt and precipitation of the free base can occur depending on the experimental conditions and properties of the molecule. The dissolution of... |
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US and UK versions of the EQ-5D preference weights: does choice of preference weights make a difference?
Qual. Life Res. 16(6) , 1065-72, (2007) Most US studies that estimate EQ-5D index score generally apply the UK preference weights. We compared the validity of a newly-developed US weights to the UK weights for use of EQ-5D as a measure of health-related quality of life.Data were collected from a ra... |
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Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: introducing a diketoacid functionality into delavirdine.
Bioorg. Med. Chem. 16(7) , 3587-95, (2008) Cost and toxicity problems associated with highly active antiretroviral therapy (HAART) in HIV/AIDS treatment could be alleviated by using designed multiple ligands (DMLs). Dual inhibitors of HIV reverse transcriptase (RT) and integrase (IN) were rationally d... |
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Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses.
Protein Sci. 16(8) , 1728-37, (2007) Nonnucleoside reverse transcriptase inhibitors (NNRTI) are a group of structurally diverse compounds that bind to a single site in HIV-1 reverse transcriptase (RT), termed the NNRTI-binding pocket (NNRTI-BP). NNRTI binding to RT induces conformational changes... |
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Monitoring the development of non-nucleoside reverse transcriptase inhibitor-associated resistant HIV-1 using an electrochemiluminescence-based reverse transcriptase polymerase assay.
Anal. Biochem. 374(1) , 121-32, (2008) Reverse transcriptase (RT) plays an essential role in the HIV-1 replication process, which converts a single-strand RNA into a double-strand DNA via polymerase and RNase H activities. Therefore, inhibition of RT has been one of the primary therapeutic strateg... |
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Progress of bis(heteroaryl)piperazines (BHAPs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) against human immunodeficiency virus type 1 (HIV-1).
Mini Rev. Med. Chem. 10(1) , 62-72, (2010) Since the first case of acquired immunodeficiency syndrome (AIDS) was reported in 1981, AIDS, as the global disease affecting 33.2 million people in 2007, has always been an unsolved problem worldwide. Reverse transcriptase (RT) is a crucial enzyme in the lif... |