Alpha-Ketoglutaric acid sodium salt
Alpha-Ketoglutaric acid sodium salt structure
|
Common Name | Alpha-Ketoglutaric acid sodium salt | ||
|---|---|---|---|---|
| CAS Number | 22202-68-2 | Molecular Weight | 168.08000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C5H5NaO5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
|
Inverse solvent isotope effects arising from substrate triggering in the factor inhibiting hypoxia inducible factor.
Biochemistry 52(9) , 1594-602, (2013) Oxygen homeostasis plays a critical role in angiogenesis, erythropoiesis, and cell metabolism. Oxygen homeostasis is set by the hypoxia inducible factor-1α (HIF-1α) pathway, which is controlled by factor inhibiting HIF-1α (FIH). FIH is a non-heme Fe(II), α-ke... |
|
|
[Catalytic properties of enzymes from Erwinia carotovora involved in transamination of phenylpyruvate].
Prikl. Biokhim. Mikrobiol. 49(2) , 129-35, (2013) Km for L-phenylalanine, L-glutamic acid, L-aspartic acid, and the corresponding keto acids were calculated, as well as Vmax, was measured for the following pairs of substrates: L-phenylalanine-2-ketoglutarate, L-phenylalanine-oxaloacetate, L-glutamic acid-phe... |
|
|
Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.
Biochemistry 52(26) , 4563-77, (2013) The human, cytosolic enzyme isocitrate dehydrogenase 1 (IDH1) reversibly converts isocitrate to α-ketoglutarate (αKG). Cancer-associated somatic mutations in IDH1 result in a loss of this normal function but a gain in a new or neomorphic ability to convert αK... |
|
|
(-) Epicatechin attenuates mitochondrial damage by enhancing mitochondrial multi-marker enzymes, adenosine triphosphate and lowering calcium in isoproterenol induced myocardial infarcted rats.
Food Chem. Toxicol. 53 , 409-16, (2013) Cardiac mitochondrial damage plays an important role in the pathology of myocardial infarction. The protective effects of (-) epicatechin on cardiac mitochondrial damage in isoproterenol induced myocardial infarction were evaluated in rats. Rats were pretreat... |
|
|
Biochemical characterization of a nitrogen-type phosphotransferase system reveals that enzyme EI(Ntr) integrates carbon and nitrogen signaling in Sinorhizobium meliloti.
J. Bacteriol. 196(10) , 1901-7, (2014) In Sinorhizobium meliloti, catabolite repression is influenced by a noncanonical nitrogen-type phosphotransferase system (PTS(Ntr)). In this PTS(Ntr), the protein HPr is phosphorylated on histidine-22 by the enzyme EI(Ntr) and the flux of phosphate through th... |
|
|
The ratio of acetate-to-glucose oxidation in astrocytes from a single 13C NMR spectrum of cerebral cortex.
J. Neurochem. 132(1) , 99-109, (2015) The (13) C-labeling patterns in glutamate and glutamine from brain tissue are quite different after infusion of a mixture of (13) C-enriched glucose and acetate. Two processes contribute to this observation, oxidation of acetate by astrocytes but not neurons,... |
|
|
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells.
Nature 518(7539) , 413-6, (2015) The role of cellular metabolism in regulating cell proliferation and differentiation remains poorly understood. For example, most mammalian cells cannot proliferate without exogenous glutamine supplementation even though glutamine is a non-essential amino aci... |
|
|
TCA cycle involved enzymes SucA and Kgd, as well as MenD: efficient biocatalysts for asymmetric C-C bond formation.
Org. Lett. 15(3) , 452-5, (2013) Asymmetric mixed carboligation reactions of α-ketoglutarate with different aldehydes were explored with the thiamine diphosphate dependent enzymes SucA from E. coli, Kgd from Mycobacterium tuberculosis, and MenD from E. coli. All three enzymes proved to be ef... |
|
|
Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function.
Org. Lett. 15(18) , 4662-5, (2013) A 2-oxoglutaric acid (2-OG) probe bearing a methylene group introduced at the C4 position and a vinyl group to replace the carbonyl group at the C2 position elicited characteristic affinity for NtcA, the 2-OG receptor, while maintaining the signaling function... |
|
|
Improved production of secreted heterologous enzyme in Bacillus subtilis strain MGB874 via modification of glutamate metabolism and growth conditions.
Microb. Cell Fact. 12 , 18, (2013) The Bacillus subtilis genome-reduced strain MGB874 exhibits enhanced production of exogenous extracellular enzymes under batch fermentation conditions. We predicted that deletion of the gene for RocG, a bi-functional protein that acts as a glutamate dehydroge... |