(+)-MK 801 Maleate
(+)-MK 801 Maleate structure
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Common Name | (+)-MK 801 Maleate | ||
|---|---|---|---|---|
| CAS Number | 77086-22-7 | Molecular Weight | 337.369 | |
| Density | N/A | Boiling Point | 541ºC at 760 mmHg | |
| Molecular Formula | C20H19NO4 | Melting Point | 183-185ºC | |
| MSDS | USA | Flash Point | 281ºC | |
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Role of ionotropic glutamate receptors in delay and probability discounting in the rat.
Psychopharmacol. Ser. 232(7) , 1187-96, (2015) Discounting of delayed and probabilistic reinforcement is linked to increased drug use and pathological gambling. Understanding the neurobiology of discounting is important for designing treatments for these disorders. Glutamate is considered to be involved i... |
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The role of the glutamatergic NMDA receptor in nanosilver-evoked neurotoxicity in primary cultures of cerebellar granule cells.
Toxicology 315 , 38-48, (2014) Nanoparticles are known to enter the vertebrate brain, but little is known about their neurotoxicity. The aim of this study is to investigate mechanisms of the contribution of AgNPs to neuronal cell death using primary cultures of rat cerebellar granule cells... |
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The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis.
J. Neural Transm. Gen. Sect. 117(11) , 1319-25, (2010) Tofisopam is a member of the 2,3-benzodiazepine compound family which is marketed for the treatment of anxiety in some European countries. In contrast to classical 1,4-benzodiazepines, the compound does not bind to the benzodiazepine binding site of the γ-ami... |
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Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal.
J. Pharmacol. Exp. Ther. 355 , 496-505, (2015) Opioid withdrawal causes a dysphoric state that can lead to complications in pain patients and can propagate use in drug abusers and addicts. Opioid withdrawal changes the activity of neurons in the nucleus accumbens, an area rich in both opioid-binding mu op... |
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Uliginosin B, a natural phloroglucinol derivative, presents a multimediated antinociceptive effect in mice.
J. Pharm. Pharmacol. 66(12) , 1774-85, (2014) Investigate the involvement of monoaminergic and glutamatergic systems on the antinociceptive and ataxic effects of uliginosin B, which we have already demonstrated to be a promising molecular scaffold to develop new analgesic drugs.Uliginosin B was obtained ... |
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N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic neuritis.
J. Neuropathol. Exp. Neurol. 73(6) , 507-18, (2014) Optic neuritis is a common clinical manifestation of the chronic inflammatory CNS disease multiple sclerosis that can result in persistent visual impairment caused by degeneration of optic nerve axons and apoptosis of retinal ganglion cells (RGCs). Using a mo... |
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Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats.
Psychopharmacology 232 , 3009-17, (2015) Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agoni... |
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Involvement of NMDA receptors in nicotine-mediated central control of hypotensive effects.
Chin. J. Physiol. 55(5) , 337-45, (2012) It is known that enrichment of glutamatergic transmission in the nucleus tractus solitarii (NTS) plays an important role in central cardiovascular regulation. Our previous study demonstrated that nicotine decreased blood pressure and heart rate in the NTS pro... |
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Effect of co-treatment with mirtazapine and risperidone in animal models of the positive symptoms of schizophrenia in mice.
Pharmacol. Rep. 64(6) , 1567-72, (2012) Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve the positive, negative and some cognitive symptoms of schizophrenia.The present study was aimed at examining the effect of mirtaz... |
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Role of glutamate receptors and nitric oxide on the effects of glufosinate ammonium, an organophosphate pesticide, on in vivo dopamine release in rat striatum.
Toxicology 311(3) , 154-61, (2013) The purpose of the present work was to assess the possible role of glutamatergic receptors and nitric oxide (NO) production on effects of glufosinate ammonium (GLA), an organophosphate pesticide structurally related to glutamate, on in vivo striatal dopamine ... |