metaphit methanesulfonate
metaphit methanesulfonate structure
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Common Name | metaphit methanesulfonate | ||
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| CAS Number | 99287-12-4 | Molecular Weight | 396.56700 | |
| Density | N/A | Boiling Point | 433.7ºC at 760 mmHg | |
| Molecular Formula | C19H28N2O3S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 216.1ºC | |
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Acylation of sigma receptors by Metaphit, an isothiocyanate derivative of phencyclidine.
Eur. J. Pharmacol. 161 , 273-277, (1989) Pretreatment of guinea pig brain membranes with 1-[1-(3-isothiocyanatophenyl)cyclohexyl]piperidine (Metaphit) caused irreversible and differential inhibition of ligand binding to sigma (sigma) receptors. The concentration of Metaphit required to produce 50% i... |
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Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors.
Eur. J. Pharmacol. 140 , 267, (1987) Metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, has been considered as a potentially specific PCP antagonist. In whole animal studies, however, metaphit has been shown to have either a... |
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Long-term blockade of the dopamine uptake complex by metaphit, an isothiocyanate derivative of phencyclidine.
Synapse 3 , 239-245, (1989) [3H]Mazindol was used to label the dopamine uptake complex in mouse striatum in vitro in the presence and absence of metaphit, an isothiocyanate derivative of phencyclidine. In some experiments, metaphit was present in the incubation fluid throughout the proc... |