e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Ligand??Free Pd??Catalyzed Carbonylative Cross??Coupling Reactions under Atmospheric Pressure of Carbon Monoxide: Synthesis of Aryl Ketones and …

H Li, M Yang, Y Qi, J Xue

Index: Li, Hongling; Yang, Min; Qi, Yanxing; Xue, Jijun European Journal of Organic Chemistry, 2011 , # 14 p. 2662 - 2667

Full Text: HTML

Citation Number: 25

Abstract

Abstract The carbonylative Suzuki cross-coupling reactions of boronic acids with aryl iodides catalyzed by Pd 2 (dba) 3 as a ligand-free catalyst under atmospheric pressure of carbon monoxide has been firstly developed. Under mild reaction conditions, a broad range of aryl/heteroaryl iodides and aryl/heteroaryl boronic acids were selectively coupled to afford the corresponding diaryl ketones in good to excellent yields at low catalyst loadings (0.05 ...

2-Iodothiophene Structure

2-Iodothiophene

3-Thienylboronic acid Structure

3-Thienylboroni...

carbon monoxide Structure

carbon monoxide

~67%

Methanone,2-thienyl-3-thienyl- Structure

Methanone,2-thi...

3-Iodopyridine Structure

2-Furanboronic acid Structure

2-Furanboronic acid

carbon monoxide Structure

carbon monoxide

~80%

3-(2-FURANOYL)PYRIDINE Structure

3-(2-FURANOYL)P...

3-Iodopyridine Structure

carbon monoxide Structure

carbon monoxide

Phenylboronic acid Structure

Phenylboronic acid

~99%

Phenyl(3-pyridinyl)methanone Structure

Phenyl(3-pyridi...

3-Iodopyridine Structure

carbon monoxide Structure

carbon monoxide

N/A Structure

~90%

4-Methoxyphenyl(3-pyridinyl) ketone Structure

4-Methoxyphenyl...

Iodobenzene Structure

carbon monoxide Structure

carbon monoxide

4-Tolylboronic acid Structure

4-Tolylboronic acid

~98%

4-methybenzophenone Structure

4-methybenzophenone

3-Iodopyridine Structure

carbon monoxide Structure

carbon monoxide

4-Bromophenylboronic Acid Structure

4-Bromophenylbo...

~93%

3-(4-BROMOBENZOYL)PYRIDINE Structure

3-(4-BROMOBENZO...

2-Furanboronic acid Structure

2-Furanboronic acid

carbon monoxide Structure

carbon monoxide

4-Iodoanisole Structure

~65%

2-(4-METHOXYBENZOYL)FURAN Structure

2-(4-METHOXYBEN...

carbon monoxide Structure

carbon monoxide

Methyl 4-iodobenzoate Structure

Methyl 4-iodobe...

4-Tolylboronic acid Structure

4-Tolylboronic acid

~93%

methyl 4-(4-methylbenzoyl)benzoate Structure

methyl 4-(4-met...

Iodobenzene Structure

carbon monoxide Structure

carbon monoxide

(4-Chlorophenyl)boronic acid Structure

(4-Chlorophenyl...

~89%

4-Chlorobenzophenone Structure

4-Chlorobenzophenone

2-Iodothiophene Structure

2-Iodothiophene

carbon monoxide Structure

carbon monoxide

N/A Structure

~94%

2-(p-Methoxybenzoyl)thiophene Structure

2-(p-Methoxyben...

3-Iodopyridine Structure

3-Thienylboronic acid Structure

3-Thienylboroni...

carbon monoxide Structure

carbon monoxide

~84%

pyridin-3-yl(thien-3-yl)methanone (en)Methanone, 3-pyridinyl-3-thienyl- (en) Structure

pyridin-3-yl(th...

2-Iodothiophene Structure

2-Iodothiophene

carbon monoxide Structure

carbon monoxide

4-Bromophenylboronic Acid Structure

4-Bromophenylbo...

~80%

(4-bromophenyl)-thiophen-2-ylmethanone Structure

(4-bromophenyl)...

2-Iodothiophene Structure

2-Iodothiophene

2-Furanboronic acid Structure

2-Furanboronic acid

carbon monoxide Structure

carbon monoxide

~81%

furan-2-yl(thiophen-2-yl)methanone Structure

furan-2-yl(thio...