Arylethenylbenzofuroxan Derivatives as Drugs for Chagas Disease: Multigram Batch Synthesis using a Wittig− Boden Process‡

W Porcal, A Merlino, M Boiani, A Gerpe…

Index: Porcal, Williams; Merlino, Alicia; Boiani, Mariana; Gerpe, Alejandra; Gonzalez, Mercedes; Cerecetto, Hugo Organic Process Research and Development, 2008 , vol. 12, # 2 p. 156 - 162

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Citation Number: 19

Abstract

In the present work, we developed robust processes for the preparation of new antitrypanosomal benzofuroxans, E and Z isomers of 5-arylethenylbenzo [1, 2-c] 1, 2, 5- oxadiazole N 1-oxide 1–6, in multigram batch through Wittig− Boden conditions as the key synthetic step. In these conditions, the generation of the benzofurazans, as secondary byproduct, was minimized.