Efficient Chemoenzymatic Synthesis of Enantiomerically Pure α??Amino Acids

…, B Napierski, HP Rebenstock, EW Holla

Index: Beller, Matthias; Eckert, Markus; Geissler, Holger; Napierski, Bernd; Rebenstock, Heinz-Peter; Holla, E. Wolfgang Chemistry - A European Journal, 1998 , vol. 4, # 5 p. 935 - 941

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Citation Number: 50

Abstract

Abstract A “state of the art” route to enantiomerically pure synthetic α-amino acids on a multigram scale from commonly available starting materials (below) is described; it relies on the combination of palladium-catalyzed amidocarbonylation and enantioselective enzymatic hydrolysis.