L-Methionine

Modify Date: 2026-06-30 02:18:12

L-Methionine Structure
L-Methionine structure
Common Name L-Methionine
CAS Number 63-68-3 Molecular Weight 149.211
Density 1.2±0.1 g/cm3 Boiling Point 306.9±37.0 °C at 760 mmHg
Molecular Formula C5H11NO2S Melting Point 284 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 139.4±26.5 °C

 Use of L-Methionine


L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name L-methionine
Synonym More Synonyms

 L-Methionine Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
Related Catalog
Target

Human Endogenous Metabolite

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.2±0.1 g/cm3
Boiling Point 306.9±37.0 °C at 760 mmHg
Melting Point 284 °C (dec.)(lit.)
Molecular Formula C5H11NO2S
Molecular Weight 149.211
Flash Point 139.4±26.5 °C
Exact Mass 149.051056
PSA 88.62000
LogP 0.37
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.531
InChIKey FFEARJCKVFRZRR-BYPYZUCNSA-N
SMILES CSCCC(N)C(=O)O
Water Solubility Soluble

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PD0457000
CHEMICAL NAME :
Methionine, L-
CAS REGISTRY NUMBER :
63-68-3
LAST UPDATED :
199710
DATA ITEMS CITED :
24
MOLECULAR FORMULA :
C5-H11-N-O2-S
MOLECULAR WEIGHT :
149.23
WISWESSER LINE NOTATION :
QVYZ2S1 -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
36 gm/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Immunological Including Allergic - uncharacterized
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4328 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>9500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
21600 mg/kg/60D-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - leukopenia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
26100 mg/kg
SEX/DURATION :
female 10-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
14720 mg/kg
SEX/DURATION :
female 10-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
35 gm/kg
SEX/DURATION :
female 2 week(s) pre-mating female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TEST SYSTEM :
Rodent - guinea pig
DOSE/DURATION :
500 mg/kg
REFERENCE :
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,190a,1970 *** REVIEWS *** TOXICOLOGY REVIEW JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 22,2,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81891 No. of Facilities: 273 (estimated) No. of Industries: 5 No. of Occupations: 17 No. of Employees: 12017 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81891 No. of Facilities: 1116 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 28520 (estimated) No. of Female Employees: 17038 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F
Risk Phrases R33
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS PD0457000
HS Code 2930400000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2930400000

 Articles358

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

The Arabidopsis cellulose synthase complex: a proposed hexamer of CESA trimers in an equimolar stoichiometry.

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Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Drug Des. Devel. Ther. 9 , 1555-84, (2015)

Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN823...

A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.

J. Virol. 89(9) , 4918-31, (2015)

The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early ...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

S-methionine
MFCD00063097
(S)-2-amino-4-(methylthio)-Butanoic acid
EINECS 200-562-9
L-α-Amino-γ-methylmercaptobutyric acid
Methionine (VAN)
(L)-Methionine
Met-bNA
2-Amino-4-methylthiobutanoic acid (S)-
L-a-Amino-g-methylmercaptobutyric Acid
Methionine, L- (8CI)
(2S)-2-amino-4-(methylsulfanyl)butanoic acid
Methionine (USP)
N-L-Methionyl-2-naphthylamine
N-L-Methionyl-2-naphthylamin
L-Methionyl b-naphthylamide
(2S)-2-Amino-4-methylsulfanylbutanoic acid
Methionine
Methionine b-naphthylamide
L-Methionine
l-met
(S)-(-)-Methionine
Met
L-Methionine (JP15)
H-Met-OH
L-Methionin

 L-Methionine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of L-methionine?
A: Related upstream materials(CAS) of L-methionine: 88153-97-3;10332-17-9;59-51-8;90508-21-7;115481-99-7;71989-28-1;120369-52-0;485-80-3.
Q: What is the polar surface area (PSA) of L-methionine?
A: Polar surface area (PSA) of L-methionine is 88.62000.
Q: What are the uses of L-methionine?
A: Main uses of L-methionine: L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
Q: What is the CAS number of L-methionine?
A: CAS number of L-methionine is 63-68-3.
Q: What is the melting point of L-methionine?
A: Melting point of L-methionine is 284 °C (dec.)(lit.).
Q: What is the boiling point of L-methionine?
A: Boiling point of L-methionine is 306.9±37.0 °C at 760 mmHg.
Q: What is the English name of L-methionine?
A: The English name of L-methionine is L-methionine.
Q: What is the LogP of L-methionine?
A: LogP of L-methionine is 0.37.
Q: How is the water solubility of L-methionine?
A: Water solubility of L-methionine: Soluble.
Q: What is the SMILES notation of L-methionine?
A: SMILES notation of L-methionine is CSCCC(N)C(=O)O.

 L-Methioninefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
BioBioPha
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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