Liquid-Phase Organic Synthesis of Thiazoles Using Poly (ethylene glycol)–Bound Sulfonyl Chloride Resin

XL Liu, QY Wang, SR Sheng, C Xu…

Index: Liu, Xiao-Ling; Wang, Qiu-Ying; Sheng, Shou-Ri; Xu, Chen; Cai, Ming-Zhong Synthetic Communications, 2008 , vol. 38, # 19 p. 3338 - 3345

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Citation Number: 6

Abstract

Abstract Reaction of poly (ethylene glycol)(PEG)–bound sulfonic acid with thionyl chloride formed difunctionalized PEG-bound sulfonyl chloride, which was treated with α- hydroxyketones, followed by treatment with thioamides in the presence of potassium carbonate, to afford thiazoles in good yields with a facile workup procedure.