Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy) ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase

…, R Ragno, S Massa, R Loddo, C Murgioni…

Index: Peet, Norton P.; Sunder, Shyam; Barbuch, Robert J.; Whalon, Michael R.; Huber, Edward W.; Huffman, John C. Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1611 - 1618

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Citation Number: 71

Abstract

... J. Med. ... 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (5−17) or 1-(3-hydroxypropyl)-2-methyl-5- nitroimidazole 7 (18) in the presence of p-toluenesulfonic acid ... PBr 3 , diethyl ether, RT, 4h; (b) 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, K 2 CO 3 , acetone, reflux, 7 days; (c) 1-(2 ...