e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides

A Mitsch, P Wißner, K Silber, P Haebel, I Sattler…

Index: Mitsch, Andreas; Wissner, Pia; Silber, Katrin; Haebel, Peter; Sattler, Isabel; Klebe, Gerhard; Schlitzer, Martin Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4585 - 4600

Full Text: HTML

Citation Number: 26

Abstract

... Downloading zip file containing 3 articles... JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry. Volume 12, Issue 17, 1 September 2004, Pages 4585–4600. Cover image Cover image. ... 19 In this study, we describe extensive variation of the terminal aryl residue of the arylfuryl moiety to establish some structure–activity relationships. 2. Chemistry. ...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

4-Acetylphenylboronic acid Structure

4-Acetylphenylb...

~68%

5-(4-ACETYL-PHENYL)-FURAN-2-CARBALDEHYDE Structure

5-(4-ACETYL-PHE...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

4-Cyanophenylboronic acid Structure

4-Cyanophenylbo...

~46%

4-(5-FORMYL-FURAN-2-YL)-BENZONITRILE Structure

4-(5-FORMYL-FUR...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

1-Naphthaleneboronic acid Structure

1-Naphthalenebo...

~82%

CHEMBRDG-BB 5255316 Structure

CHEMBRDG-BB 5255316

2-Formylfuran-5-boronic acid Structure

2-Formylfuran-5...

Methyl 4-bromobenzoate Structure

Methyl 4-bromob...

~70%

Methyl 4-(5-formylfuran-2-yl)benzoate Structure

Methyl 4-(5-for...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

4-Tolylboronic acid Structure

4-Tolylboronic acid

~73%

5-(4-METHYLPHENYL)-2-FURALDEHYDE Structure

5-(4-METHYLPHEN...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

~%

3-(5-PHENYL-FURAN-2-YL)-ACRYLIC ACID Structure

3-(5-PHENYL-FUR...

Phenylboronic acid Structure

Phenylboronic acid

~%

3-(5-PHENYL-FURAN-2-YL)-ACRYLIC ACID Structure

3-(5-PHENYL-FUR...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

[4-(Trifluoromethoxy)phenyl]boronic acid Structure

[4-(Trifluorome...

~91%

5-(4-(Trifluoromethoxy)phenyl)furan-2-carbaldehyde Structure

5-(4-(Trifluoro...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

4-Fluorobenzeneboronic acid Structure

4-Fluorobenzene...

~91%

5-(4-Fluorophenyl)-furan-2-carbaldehyde Structure

5-(4-Fluorophen...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

~%

3-[5-(4-methoxyphenyl)furan-2-yl]prop-2-enoic acid Structure

3-[5-(4-methoxy...

4-Methoxyphenylboronic acid Structure

4-Methoxyphenyl...

~%

3-[5-(4-methoxyphenyl)furan-2-yl]prop-2-enoic acid Structure

3-[5-(4-methoxy...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

2-Naphthaleneboronic acid Structure

2-Naphthalenebo...

~83%

5-naphthalen-2-ylfuran-2-carbaldehyde Structure

5-naphthalen-2-...

4-Tolylboronic acid Structure

4-Tolylboronic acid

~%

3-(5-P-TOLYL-FURAN-2-YL)-ACRYLIC ACID Structure

3-(5-P-TOLYL-FU...

5-Bromo-2-furaldehyde Structure

5-Bromo-2-fural...

~%

3-(5-P-TOLYL-FURAN-2-YL)-ACRYLIC ACID Structure

3-(5-P-TOLYL-FU...

Malonic acid Structure

5-(3-trifluoromethyl-phenyl)-furan-2-carbaldehyde Structure

5-(3-trifluorom...

~86%

3-[5-[3-(trifluoromethyl)phenyl]furan-2-yl]prop-2-enoic acid Structure

3-[5-[3-(triflu...