Journal of medicinal chemistry

Novel bis [1, 6-dihydro-6, 6-dimethyl-1, 3, 5-triazine-2, 4-diamines] as antitrypanosomal agents

WR Turner, LM Werbel

Index: Turner, William R.; Werbel, Leslie M. Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1728 - 1740

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Citation Number: 17

Abstract

A series of novel 1, 1'-(4, l-phenylene) bis [1, 6-dihydro-6, 6-dimethyl-1, 3, 5-triazine-2, 4- diamines] was prepared and evaluated for activity against Trypanosoma rhodesiense in mice. The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed. The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends ...