Synthesis and study of the neurotropic action of 2-substituted methanoisoindoles

…, IA Markushina, GE Marinicheva, TB Merkulova…

Index: Lebedev, A. A.; Markushina, I. A.; Marinicheva, G. E.; Merkulova, T. B.; Bazhmina, M. Yu. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 4 p. 252 - 256 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 4 p. 38 - 42

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Citation Number: 4

Abstract

2-Arylamino-6-methylnicotinic Acid Alkylamides (V-XIII). A solution of 0.01 mole of the 2- chloro-6-methylnicotinic acid alkylamide and 0.01 mole of the arylamine in 20 ml of 50% acetic acid was boiled for 6 h, cooled, and neutralized with a 10% solution of sodium hydroxide. The precipitate which separated was filtered off and recrystallized from a mixture of benzene and hexane (1: 2). The hydrochlorides of V-XIII were obtained by passing dry ...