Tetrahedron

Nickel-catalysed selective N-arylation or N, N′-diarylation of secondary diamines

E Brenner, R Schneider, Y Fort

Index: Brenner, Eric; Schneider, Raphael; Fort, Yves Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924

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Citation Number: 24

Abstract

The selective synthesis of N-aryl or N, N′-diaryl piperazines and trimethylene (bis) piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni (0) associated to 2, 2′-bipyridine is described. The Ni/2, 2′-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1, 4-diaryl piperazines is reported.