3-[(3′-Hydroxymethyl)-4′-hydroxybutyl] imidazo [4, 5-b] pyridines—novel antiviral agents

DJ Cundy, G Holan, M Otaegui, GW Simpson

Index: Cundy, Darren J.; Holan, George; Otaegui, Michelle; Simpson, Gregory W. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 669 - 674

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Citation Number: 23

Abstract

Derivatives of 3-and 1-(4′-hydroxy-3′-(hydroxymethyl) butyl)-imidazo [4, 5-b] pyridine were prepared in several steps from 2-amino-5-chloropyridine. Selected compounds were evaluated against human cytomeglovirus (HCMV), herpes simplex virusus (HSV1/HSV2) and varicella zoster virus (VZV). Details of their synthesis and biological activities are presented.