Journal of the Chinese Chemical Society

Bromelain catalyzed synthesis of peptides in organic solvent

DF Tai, SL Fu

Index: Tai, Dar-Fu; Fu, Shu-Lin Journal of the Chinese Chemical Society, 2003 , vol. 50, # 1 p. 179 - 183

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Citation Number: 7

Abstract

Abstract For the first time, immobilized bromelain was shown to maintain high catalytic activity in organic solvent and to form peptide bonds. It requires only 7 hours to obtain Cbz- Gly-l-Leu-OMe in 85% yield. The precursor of aspartame (Cbz-l-Asp-l-Phe-OMe) and other dipeptides were also synthesized by this method.