Tetrahedron letters

A new route to amino-2-propanol structures with adrenergic β-blocker activity using low valent titanium

JL Bermudez, C Del Campo, JV Sinisterra, EF Llama

Index: Bermudez; Del Campo; Sinisterra; Llama Tetrahedron Letters, 1997 , vol. 38, # 23 p. 4137 - 4140

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Citation Number: 3

Abstract

Amino-2-propanol structures can be obtained by addition to dibenzyl acetals of in situ generated dihalocarbenes using LVT (Low Valent Titanium). This methodology can be used to obtain adrenergic β-blockers with amino-2-propanol structure. Tetrahalomethanes are the best dihalocarbene precursors. The yields obtained using halofluoromethanes can be increased by addition of carbontetrachloride. A process that can imply halogen transfer ...