Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity

J Zheng, L Deng, M Chen, X Xiao, S Xiao, C Guo…

Index: Zheng, Jing; Deng, Lijuan; Chen, Minfeng; Xiao, Xuzhi; Xiao, Shengwei; Guo, Cuiping; Xiao, Gaokeng; Bai, Liangliang; Ye, Wencai; Zhang, Dongmei; Chen, Heru European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 158 - 167

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Citation Number: 5

Abstract

Abstract Thorough simplification of vinca alkaloids based on pharmacophore similarity has been conducted. A concise process for the syntheses of target compounds was successfully developed with yields from poor to excellent (19–98%). Cell growth inhibitory activities of these synthesized compounds were evaluated in five cancer cell lines including MCF-7, MDA-MB-231, HepG2, HepG2/ADM and K562. Almost all compounds exhibited moderate ...