Mild regioselective halogenation of activated pyridines with N-bromosuccinimide

…, JF Rodriguez, M Santos, MA Sanz-Tejedor…

Index: Canibano; Rodriguez; Santos; Sanz-Tejedor; Carreno; Gonzalez; Garcia-Ruano Synthesis, 2001 , # 14 p. 2175 - 2179

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Citation Number: 53

Abstract

Abstract Regioselective mono and dihalogenations of amino, hydroxy and methoxy pyridines (2-, 3-, and 4-substituted) as well as 2, 6-dimethoxy pyridine with N- bromosuccinimide in different solvents have been studied. Reactivity of the substrates decreases in the order amino> hydroxy> methoxy and regioselectivity depends on the position of the substituent (2-substituted> 3-substituted). In most of the cases we obtained ...