Mixed Mg/Li amides of the type R2NMgCl⋅ LiCl as highly efficient bases for the regioselective generation of functionalized aryl and heteroaryl magnesium …

A Krasovskiy, V Krasovskaya…

Index: Krasovskiy, Arkady; Krasovskaya, Valeria; Knochel, Paul Angewandte Chemie - International Edition, 2006 , vol. 45, # 18 p. 2958 - 2961

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Citation Number: 357

Abstract

isolated in 81% yield. In strong contrast, the sterically more hindered and less aggregated reagent 5b led to complete magnesiation within 2 h at 258C. Remarkably, only 1.1 equiv of this base was required to achieve complete metalation. The resulting Grignard reagent 6 provided, after iodolysis, the isoquinoline 7a in 92% yield (entry 1, Table 1).