European journal of medicinal chemistry

Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling …

AM Alaa

Index: Abdel-Aziz, Alaa A.-M. European Journal of Medicinal Chemistry, 2007 , vol. 42, # 5 p. 614 - 626

Full Text: HTML

Citation Number: 103

Abstract

Versatile method has been developed for synthesis of N-substituted imides. Thus, acid anhydrides, imides and dicarboxylic acids were successfully subjected to dehydrative cyclization with substituted amines using DPPOx and Et3N to afford N-substituted imides under mild conditions. The DNA binding and apoptosis induction were investigated with regard to their potential utility as cytotoxic agents. Molecular modeling methods are used ...