Rational catalysis design on the basis of mechanistic understanding: Highly efficient Pd-catalyzed cyanation of aryl bromides with NaCN in recyclable solvents

AV Ushkov, VV Grushin

Index: Ushkov, Alexander V.; Grushin, Vladimir V. Journal of the American Chemical Society, 2011 , vol. 133, # 28 p. 10999 - 11005

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Citation Number: 58

Abstract

Rational catalysis design on the basis of a detailed mechanistic understanding has been used to successfully develop the first efficient general Pd-catalyzed aromatic cyanation reaction under the highly sought after practicable conditions:(i) MCN (M= Na or K) as a cyanide source;(ii) low-boiling recyclable solvents; and (iii) minimal quantities of inexpensive, nontoxic promoters. The developed catalytic reaction converts aromatic ...