e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Journal of medicinal chemistry

Potential neuroleptic agents. 2, 6-Dialkoxybenzamide derivatives with potent dopamine receptor blocking activities

L Florvall, SO Oegren

Index: Florvall, Lennart; Oegren, Sven-Ove Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286

Full Text: HTML

Citation Number: 93

Abstract

A series of some novel N-(1-ethyl-2-pyrrolidinylmethy1) benzamides was synthesized and tested for dopamine receptor blockade in vivo by the ability to block the apomorphine syndrome in the rat. Several compounds were considerably more potent than sulpiride as dopamine receptor blockers and displayed low liability to induce extrapyramidal side effects (catalepsy) in the rat. The blockade of dopamine receptor activity in vivo was mainly ...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~%

2-((3,5-Dichloro-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidine Structure

2-((3,5-Dichlor...

3,5-DICHLORO-2,6-DIMETHOXYBENZOIC ACID Structure

3,5-DICHLORO-2,...

~%

2-((3,5-Dichloro-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidine Structure

2-((3,5-Dichlor...

2-(Aminomethyl)-1-ethylpyrrolidine Structure

2-(Aminomethyl)...

3,5-dichloro-2,6-dimethoxybenzoyl chloride Structure

3,5-dichloro-2,...

~%

2-((3,5-Dichloro-2,6-dimethoxybenzamido)methyl)-1-ethylpyrrolidine Structure

2-((3,5-Dichlor...

3-bromo-5-chloro-2,6-dimethoxybenzoate Structure

3-bromo-5-chlor...

~%

3-bromo-5-chloro-2,6-dimethoxybenzoyl chloride Structure

3-bromo-5-chlor...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~%

3-bromo-5-chloro-2,6-dimethoxybenzoyl chloride Structure

3-bromo-5-chlor...

3-chloro-2,6-dimethoxybenzoic acid Structure

3-chloro-2,6-di...

~%

3-bromo-5-chloro-2,6-dimethoxybenzoyl chloride Structure

3-bromo-5-chlor...

3-bromo-2,6-dimethoxybenzoic acid Structure

3-bromo-2,6-dim...

~%

3-bromo-5-chloro-2,6-dimethoxybenzoyl chloride Structure

3-bromo-5-chlor...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~%

3,5-dichloro-2,6-dimethoxybenzoyl chloride Structure

3,5-dichloro-2,...

Bromoethane Structure

2,6-Dihydroxybenzoic acid Structure

2,6-Dihydroxybe...

~%

ETHYL-2 6-DIETHOXYBENZOATE Structure

ETHYL-2 6-DIETH...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~%

3-bromo-5-chloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxy-benz amide Structure

3-bromo-5-chlor...

3-chloro-2,6-dimethoxybenzoic acid Structure

3-chloro-2,6-di...

~%

3-bromo-5-chloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxy-benz amide Structure

3-bromo-5-chlor...

3-bromo-2,6-dimethoxybenzoic acid Structure

3-bromo-2,6-dim...

~%

3-bromo-5-chloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxy-benz amide Structure

3-bromo-5-chlor...

3-bromo-5-chloro-2,6-dimethoxybenzoate Structure

3-bromo-5-chlor...

~%

3-bromo-5-chloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxy-benz amide Structure

3-bromo-5-chlor...

2-(Aminomethyl)-1-ethylpyrrolidine Structure

2-(Aminomethyl)...

3-bromo-5-chloro-2,6-dimethoxybenzoyl chloride Structure

3-bromo-5-chlor...

~%

3-bromo-5-chloro-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxy-benz amide Structure

3-bromo-5-chlor...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~%

N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxybenzamide Structure

N-[(1-ethylpyrr...

2-(Aminomethyl)-1-ethylpyrrolidine Structure

2-(Aminomethyl)...

2,6-Dimethoxybenzoyl Chloride Structure

2,6-Dimethoxybe...

~%

N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxybenzamide Structure

N-[(1-ethylpyrr...

3-bromo-2,6-dimethoxybenzoic acid Structure

3-bromo-2,6-dim...

~%

3-bromo-2,6-dimethoxybenzoyl chloride Structure

3-bromo-2,6-dim...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~%

3,5-dibromo-2,6-dimethoxybenzoyl chloride Structure

3,5-dibromo-2,6...

2,6-Diethoxybenzoic acid Structure

2,6-Diethoxyben...

~%

2,6-diethoxybenzoyl chloride Structure

2,6-diethoxyben...

2,6-Dihydroxybenzoic acid Structure

2,6-Dihydroxybe...

~%

2,6-diethoxybenzoyl chloride Structure

2,6-diethoxyben...

ETHYL-2 6-DIETHOXYBENZOATE Structure

ETHYL-2 6-DIETH...

~%

2,6-diethoxybenzoyl chloride Structure

2,6-diethoxyben...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~58%

3,5-DICHLORO-2,6-DIMETHOXYBENZOIC ACID Structure

3,5-DICHLORO-2,...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~77%

3-chloro-2,6-dimethoxybenzoic acid Structure

3-chloro-2,6-di...

ETHYL-2 6-DIETHOXYBENZOATE Structure

ETHYL-2 6-DIETH...

~%

2,6-Diethoxybenzoic acid Structure

2,6-Diethoxyben...

2,6-Dihydroxybenzoic acid Structure

2,6-Dihydroxybe...

~%

2,6-Diethoxybenzoic acid Structure

2,6-Diethoxyben...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~41%

3,5-dibromo-2,6-dimethoxybenzoic acid Structure

3,5-dibromo-2,6...

3-chloro-2,6-dimethoxybenzoic acid Structure

3-chloro-2,6-di...

~17%

3-bromo-5-chloro-2,6-dimethoxybenzoate Structure

3-bromo-5-chlor...

3-bromo-2,6-dimethoxybenzoic acid Structure

3-bromo-2,6-dim...

~80%

3-bromo-5-chloro-2,6-dimethoxybenzoate Structure

3-bromo-5-chlor...

2,6-Dimethoxybenzoic acid Structure

2,6-Dimethoxybe...

~%

3-bromo-5-chloro-2,6-dimethoxybenzoate Structure

3-bromo-5-chlor...