The Journal of Organic Chemistry

(Diisopropoxymethylsilyl) methyl Grignard reagent: a new, practically useful nucleophilic hydroxymethylating agent

K Tamao, N Ishida, M Kumada

Index: Tamao, Kohei; Ishida, Neyoshi; Kumada, Makoto Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 2120 - 2122

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Citation Number: 161

Abstract

Sir: Despite its anticipated potent utility in synthetic organic chemistry,'nucleophilic hydroxymethylation has only been described in a few scattered papers. 2 The previous approaches have limited applicability, because of the limited availability of starting materials and low functional group tolerance. We have now developed the (diisopropoxymethylsily1) methyl Grignard reagent (1) as a new nucleophilic hydroxymethylating agent that is ...