Phthalide

Modify Date: 2025-08-21 12:19:58

Phthalide Structure
Phthalide structure
Common Name Phthalide
CAS Number 87-41-2 Molecular Weight 134.132
Density 1.3±0.1 g/cm3 Boiling Point 290.0±0.0 °C at 760 mmHg
Molecular Formula C8H6O2 Melting Point 71-74 °C(lit.)
MSDS Chinese USA Flash Point 124.8±22.2 °C

 Use of Phthalide


Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant[1][2][3].

 Names

Name 2-benzofuran-1(3H)-one
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 290.0±0.0 °C at 760 mmHg
Melting Point 71-74 °C(lit.)
Molecular Formula C8H6O2
Molecular Weight 134.132
Flash Point 124.8±22.2 °C
Exact Mass 134.036774
PSA 26.30000
LogP 0.99
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.585
Water Solubility sparingly soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TI3520000
CHEMICAL NAME :
Phthalide
CAS REGISTRY NUMBER :
87-41-2
BEILSTEIN REFERENCE NO. :
0114632
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H6-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,25,1953

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36
Safety Phrases S26-S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TI3520000
HS Code 29322980

 Synthetic Route

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles27

More Articles
Development of an Immunosensor for Determination of the Fungicide Chlorothalonil in Vegetables, Using Surface Plasmon Resonance.

J. Agric. Food Chem. 63 , 6325-30, (2015)

An immunosensor based on surface plasmon resonance (SPR-sensor) was developed to analyze chlorothalonil residues and maximum residue limits (MRLs; 0.5-50 mg/kg) in vegetables in Japan. Conjugates of N...

Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides.

J. Org. Chem. 75(17) , 6043-5, (2010)

A palladium-catalyzed addition of arylboronic acids to phthalaldehyde, followed by an intramolecular lactonization to access 3-substituted phthalides, is described. The procedure tolerates a series of...

Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists.

Bioorg. Med. Chem. 20(16) , 4954-61, (2012)

On the basis of a marine fungal phthalide (paecilocin A) skeleton, we synthesized 20 analogs and evaluated them for peroxisome proliferator-activated receptor gamma (PPAR-γ) binding and activation. Am...

 Synonyms

1-Isobenzofuranone
Rabcide
EINECS 201-744-0
1(3H)-4,5,6,7-tetrachloroisobenzofuranone
Fthalide
3-oxo-1,3-dihydro-isobenzofuran
MFCD00005906
5-17-10-00007 (Beilstein Handbook Reference)
1(3H)-Isobenzofuranone
isobenzofuran-1-one
1-Phthalanone
KF-32
2-Hydroxymethylbenzoic acid, γ-lactone
PHH
4,5,6,7-tetrachloro-1(3H)-isobenzofuranone
4,5,6,7-Tetrachlorophthalidefthalide
4,5,6,7-Tetrachlor-phthalid
Phthalide
2-Benzofuran-1(3H)-one
1H-Isobenzofuran-3-one
T56 BVO DHJ
4,5,6,7-TETRACHLOROPHTHALIDE
4,5,6,7-tetrachloroisobenzofuran-1(3H)-one
Isobenzofuranone
Phthalolactone
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