Phthalide

Modify Date: 2025-08-21 12:19:58

Phthalide structure	Common Name	Phthalide
	CAS Number	87-41-2	Molecular Weight	134.132
	Density	1.3±0.1 g/cm3	Boiling Point	290.0±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₆O₂	Melting Point	71-74 °C(lit.)
	MSDS	Chinese USA	Flash Point	124.8±22.2 °C

Use of Phthalide

Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant[1][2][3].

Name	2-benzofuran-1(3H)-one
Synonym	More Synonyms

Description	Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Liu Zeng Chen, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020 Nov 15;206:112722. [2]. Chakapong Intaraudom, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353. [3]. Xin Fang, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. J Asian Nat Prod Res. 2020 Dec;22(12):1176-1187.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

References

[1]. Liu Zeng Chen, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020 Nov 15;206:112722.

[2]. Chakapong Intaraudom, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353.

[3]. Xin Fang, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. J Asian Nat Prod Res. 2020 Dec;22(12):1176-1187.

Density	1.3±0.1 g/cm3
Boiling Point	290.0±0.0 °C at 760 mmHg
Melting Point	71-74 °C(lit.)
Molecular Formula	C₈H₆O₂
Molecular Weight	134.132
Flash Point	124.8±22.2 °C
Exact Mass	134.036774
PSA	26.30000
LogP	0.99
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.585
InChIKey	WNZQDUSMALZDQF-UHFFFAOYSA-N
SMILES	O=C1OCc2ccccc21
Water Solubility	sparingly soluble

Phthalide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI3520000

CHEMICAL NAME :: Phthalide

CAS REGISTRY NUMBER :: 87-41-2

BEILSTEIN REFERENCE NO. :: 0114632

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H6-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,25,1953

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36
Safety Phrases	S26-S36-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TI3520000
HS Code	29322980

Precursor 10
CAS#:6295-21-2 3-Chloro-2-benz... CAS#:95-47-6 o-xylene CAS#:201230-82-2 carbon monoxide CAS#:5159-41-1 (2-Iodophenyl)m...
CAS#:70744-47-7 Tributyl(4-meth... CAS#:112533-09-2 [2-(hydroxymeth... CAS#:612-14-6 1,2-Phenylenedi... CAS#:18982-54-2 2-Bromobenzyl a...
CAS#:92804-32-5 3-(4-methoxyphe... CAS#:118-90-1 2-Methylbenzoic acid
DownStream 10
CAS#:108475-90-7 2-(2-methy1phen... CAS#:55453-87-7 Isoxepac CAS#:5388-42-1 1H-Isoindol-1-o... CAS#:57319-65-0 6-Amino-1,3-dih...
CAS#:496-14-0 Phthalane CAS#:34040-62-5 Methyl 2-(chlor... CAS#:42908-86-1 2-(Chloromethyl... CAS#:85-44-9 Phthalic anhydride
CAS#:55453-89-9 Acetic 2-(pheno... CAS#:40819-28-1 2-(bromomethyl)...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Development of an Immunosensor for Determination of the Fungicide Chlorothalonil in Vegetables, Using Surface Plasmon Resonance.

J. Agric. Food Chem. 63 , 6325-30, (2015)

An immunosensor based on surface plasmon resonance (SPR-sensor) was developed to analyze chlorothalonil residues and maximum residue limits (MRLs; 0.5-50 mg/kg) in vegetables in Japan. Conjugates of N...

Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides.

J. Org. Chem. 75(17) , 6043-5, (2010)

A palladium-catalyzed addition of arylboronic acids to phthalaldehyde, followed by an intramolecular lactonization to access 3-substituted phthalides, is described. The procedure tolerates a series of...

Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists.

Bioorg. Med. Chem. 20(16) , 4954-61, (2012)

On the basis of a marine fungal phthalide (paecilocin A) skeleton, we synthesized 20 analogs and evaluated them for peroxisome proliferator-activated receptor gamma (PPAR-γ) binding and activation. Am...

1-Isobenzofuranone

Rabcide

EINECS 201-744-0

1(3H)-4,5,6,7-tetrachloroisobenzofuranone

Fthalide

3-oxo-1,3-dihydro-isobenzofuran

MFCD00005906

5-17-10-00007 (Beilstein Handbook Reference)

1(3H)-Isobenzofuranone

isobenzofuran-1-one

1-Phthalanone

KF-32

2-Hydroxymethylbenzoic acid, γ-lactone

PHH

4,5,6,7-tetrachloro-1(3H)-isobenzofuranone

4,5,6,7-Tetrachlorophthalidefthalide

4,5,6,7-Tetrachlor-phthalid

Phthalide

2-Benzofuran-1(3H)-one

1H-Isobenzofuran-3-one

T56 BVO DHJ

4,5,6,7-TETRACHLOROPHTHALIDE

4,5,6,7-tetrachloroisobenzofuran-1(3H)-one

Isobenzofuranone

Phthalolactone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Phthalide
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phthalide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Phthalide
Price: ￥145.0/100g ￥455.0/500g
Purity: 99.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

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Phthalide

Use of Phthalide

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Phthalide Biological Activity

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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