Gold??Catalyzed Redox Synthesis of Imidazo [1, 2??a] pyridines using Pyridine N??Oxide and Alkynes

E Talbot, M Richardson, JM McKenna…

Index: Talbot, Eric P. A.; Richardson, Melodie; McKenna, Jeffrey M.; Toste, F. Dean Advanced Synthesis and Catalysis, 2014 , vol. 356, # 4 p. 687 - 691

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Citation Number: 29

Abstract

Abstract: A mild, catalytic, atom economical synthesis of imidazoACHTUNGTRENNUNG [1, 2-a] pyridines has been developed: catalytic dichloro (2-pyridinecarboxylato) gold [PicAuCl2] in the presence of an acid produces a range of imidazoACHTUNGTRENNUNG [1, 2-a] pyridines in good yields starting from alkynes and 2-aminopyridine N-oxides. This strategy is mild and foreseen to be of particular use for the installation of stereogenic ...