Rapid synthesis of 2, 5??disubtituted 1, 3, 4??thiadiazoles under microwave irradiation

M Lebrini, F Bentiss, M Lagrenée

Index: Lebrini, Mounim; Bentiss, Fouad; Lagrenee, Michel Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 5 p. 991 - 994

Full Text: HTML

Citation Number: 48

Abstract

Abstract The one pot, three-components condensation of aromatic aldehydes, hydrazine and sulfur in ethanol under microwave irradiation provided symmetrically 3, 5-disubstituted 1, 3, 4-thiadiazoles in high yields and good purity. This reaction must be conducted under pressure of hydrogen sulfide produced in-situ. The structure of the compounds was confirmed by 1 H, 13 C NMR, MS and elemental analysis.