Advanced Synthesis & Catalysis

… of Epoxides Catalyzed by Chromium (III)??endo, endo??2, 5??diaminonorbornane??salen [Cr (III)??DIANANE??salen] Complexes. Improved Activity, Low Catalyst Loading

A Berkessel, E Ertürk

Index: Berkessel, Albrecht; Ertuerk, Erkan Advanced Synthesis and Catalysis, 2006 , vol. 348, # 18 p. 2619 - 2625

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Citation Number: 13

Abstract

Abstract The hydrolytic kinetic resolution (HKR) of terminal epoxides, using chiral chromium (III)-salen catalysts based on DIANANE (endo, endo-2, 5-diaminonorbornane), was studied. A broad substrate scope was found for the chromium (III)-DIANANE catalysts, and very low loadings (down to 0.05 mol%) were needed to achieve high enantiomeric purities of both the remaining epoxides and the product diols (up to> 99% ee). Besides monosubstituted ...