Pharmaceutical Chemistry Journal

Peculiarities of the nitration of 2-methyl-4-methoxymethyl-5-cyano-6-pyridone in a mixture of HNO 3 and H 2 SO 4

NA Shul'ga, MV Balyakina, VI Gunar

Index: Shul'ga, N. A.; Balyakina, M. V.; Gunar, V. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 665 - 669 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1111 - 1115

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Abstract

In one of the well-known syntheses of vitamin B~, the main intermediate product, 2-methyl-3- nitro-4-methoxymethyl-5-cyano-6-pyridone (V) is produced by Nitration of 2-methyl-4- methoxymethyl-5-cyano-6-pyridone (VI) with nitric acid in acetic anhydride [3]. To replace