Pyridoxine

Modify Date: 2024-01-01 20:08:25

Pyridoxine Structure
Pyridoxine structure
 Common Name Pyridoxine
CAS Number 65-23-6 Molecular Weight 169.178
Density 1.4±0.1 g/cm3 Boiling Point 491.9±40.0 °C at 760 mmHg
Molecular Formula C8H11NO3 Melting Point 159-162ºC
MSDS USA Flash Point 251.3±27.3 °C

 Use of Pyridoxine


Pyridoxine is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

 Names

Name pyridoxine
Synonym More Synonyms

 Pyridoxine Biological Activity

Description Pyridoxine is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Pyridoxine exerts a protective potential against AD, attenuates ROS levels, decreases the expressions of cytoplasmic Nrf2, and upregulates whole-cell HO-1 expression[1].
References

[1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 491.9±40.0 °C at 760 mmHg
Melting Point 159-162ºC
Molecular Formula C8H11NO3
Molecular Weight 169.178
Flash Point 251.3±27.3 °C
Exact Mass 169.073898
PSA 73.58000
LogP -1.10
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.621
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility H2O: 0.1 g/mL at 20 °C, clear, colorless

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1300000
CHEMICAL NAME :
Pyridoxol
CAS REGISTRY NUMBER :
65-23-6
LAST UPDATED :
199707
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C8-H11-N-O3
MOLECULAR WEIGHT :
169.20
WISWESSER LINE NOTATION :
T6NJ B1 CQ D1Q E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2100 mg/kg/30D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis Behavioral - ataxia
REFERENCE :
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 35,1466,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
4800 mg/kg/17W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - local anesthetic
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 309,445,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
139 mg/kg/5Y-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 311,986,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
5143 mg/kg/17W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - local anesthetic
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 309,445,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 43,116,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 43,116,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
657 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 44,147,1940
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
966 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 40,371,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
545 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,683,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4524 No. of Facilities: 630 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 14045 (estimated) No. of Female Employees: 5607 (estimated)

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UV1350000
HS Code 29362500

 Synthetic Route

 Customs

HS Code 2936250000
Summary HS: 2936250000. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:4.0%. general tariff:20.0%

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 Synonyms

4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol
3-Hydroxy-4,5-dimethylol-a-picoline
Pyridoxine
EINECS 200-386-2
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
Pirivitol
3-hydroxy-2-Picoline-4,5-dimethanol
3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Pyridoxol
Bezatin
VITAMIN B6 COMPLEX
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-
2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine
(5-Hydroxy-6-methylpyridine-3,4-diyl)dimethanol
MFCD00006335
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