Helvetica chimica acta

Structure??Based Design and Synthesis of Regioisomeric Disubstituted Aminoanthraquinone Derivatives as Potential Anticancer Agents

HS Huang, HF Chiu, PF Yeh, CL Yuan

Index: Huang, Hsu-Shan; Chiu, Hui-Fen; Yeh, Pen-Fong; Yuan, Chun-Lung Helvetica Chimica Acta, 2004 , vol. 87, # 4 p. 999 - 1006

Full Text: HTML

Citation Number: 18

Abstract

Abstract Continuing our ongoing studies on cytotoxic substances, we report the synthesis and cytotoxic properties of a series of symmetric 1, 5-diamino-9, 10-anthraquinones with potentially bioreducible groups. Symmetric amination of 1, 5-dichloro-9, 10-anthraquinone with the appropriate primary amines in the presence of DMF furnished the structurally related aminoanthraquinone analogs 1–19. Their in vitro cytotoxic activity was evaluated ...