Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles

…, R Wang, E Bagan, CC Wang, P Wislocki…

Index: Walsh; Wang; Bagan; Wislocki; Miwa Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 150 - 156

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Citation Number: 55

Abstract

Two approaches have been used to develop nonmutagenic 5-nitroimidazoles. Both approaches are based on knowledge of the likely mechanisms by which this class of compounds cause mutagenicity. The first approach involved incorporating readily oxidizable gallate derivatives into the molecule. In one case, a very weakly mutagenic active antitrichomonal agent was obtained. The second approach involved incorporating a ...