The Synthesis of New Pyrrolidinyl Ketones

AS Radwan, FR Melek, S Negm

Index: Radwan, A. S.; Melek, F. R.; Negm, S. Journal fuer Praktische Chemie (Leipzig), 1980 , vol. 322, # 3 p. 475 - 478

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Abstract

Few reports appeared in the literature concerning the synthesis of 2-pyrrolidinyl methyl ketones [I]. The preparation of the naturally occurring alkaloid hygrine (1-methyl-2-acetonyl pyrrolidine) has been described [2]. In the present investigation, the synthesis of a series of some unknown (1-methyl-2-pyrrolidinyl)-methyl ketones (I-XIV) has been undertaken for evaluating their pharmacological potentialities in an attempt to establish a chemical- ...