e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Magnesiation Employing Grignard Reagents and Catalytic Amine. Application to the Functionalization of N-Phenylsulfonylpyrrole

A Dinsmore, DG Billing, K Mandy, JP Michael…

Index: Cadamuro, Silvano; Degani, Iacopo; Dughera, Stefano; Fochi, Rita; Gatti, Antonella; Piscopo, Laura Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 2 p. 273 - 284

Full Text: HTML

Citation Number: 24

Abstract

... for synthesizing 2,4-diacylpyrroles and their precursors containing one or two masked acyl groups. Cadamuro, Silvano; Degani, Iacopo; Dughera, Stefano; Fochi, Rita; Gatti, Antonella; Piscopo, Laura. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio ...

1-(Phenylsulfonyl)-1H-pyrrole Structure

1-(Phenylsulfon...

p-Anisoyl chloride Structure

p-Anisoyl chloride

~89%

[1-(benzenesulfonyl)pyrrol-3-yl]-(4-methoxyphenyl)methanone Structure

[1-(benzenesulf...

3-pivaloyl-1-phenylsulfonylpyrrole Structure

3-pivaloyl-1-ph...

~95%

2,2-dimethyl-1-(1H-pyrrol-3-yl)propan-1-one Structure

2,2-dimethyl-1-...

4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

~%

(4-chlorophenyl)-(1-methylpyrrol-3-yl)methanone Structure

(4-chlorophenyl...

(1-benzenesulfonyl-1H-pyrrol-3-yl)-(4-chlorophenyl)methanone Structure

(1-benzenesulfo...

Sodium Methylate Structure

Sodium Methylate

~78%

(4-CHLOROCARBONYLPHENYL)BORONICANHYDRIDE Structure

(4-CHLOROCARBON...

(4-chlorophenyl)-(1-methylpyrrol-3-yl)methanone Structure

(4-chlorophenyl...

3-Acetyl-1-(phenylsulfonyl)pyrrole Structure

3-Acetyl-1-(phe...

~98%

3-ACETYLPYRROLE Structure

3-ACETYLPYRROLE

(1-benzenesulfonyl-1H-pyrrol-3-yl)-(4-chlorophenyl)methanone Structure

(1-benzenesulfo...

Sodium Methylate Structure

Sodium Methylate

~14%

(4-CHLOROCARBONYLPHENYL)BORONICANHYDRIDE Structure

(4-CHLOROCARBON...

(4-chlorophenyl)-(1-methylpyrrol-3-yl)methanone Structure

(4-chlorophenyl...

1-(Phenylsulfonyl)-1H-pyrrole Structure

1-(Phenylsulfon...

Benzoyl chloride Structure

Benzoyl chloride

~99%

[1-(benzenesulfonyl)pyrrol-3-yl]-phenylmethanone Structure

[1-(benzenesulf...

1-(Phenylsulfonyl)-1H-pyrrole Structure

1-(Phenylsulfon...

Benzoyl chloride Structure

Benzoyl chloride

~23%

[1-(benzenesulfonyl)pyrrol-3-yl]-phenylmethanone Structure

[1-(benzenesulf...

1-(Phenylsulfonyl)-2-benzoylpyrrole Structure

1-(Phenylsulfon...

cyclohexyl(1-(phenylsulfonyl)-1H-pyrrol-3-yl)methanone Structure

cyclohexyl(1-(p...

~%

2-cyclohexylidene-1,3-benzodithiole Structure

2-cyclohexylide...

N/A Structure

~91%

Ethanone, 1,1-(1H-pyrrole-2,4-diyl)bis- (9CI) Structure

Ethanone, 1,1-(...

1-(5-(2-methylbenzo[d][1,3]dithiol-2-yl)-1H-pyrrol-3-yl)ethanone Structure

1-(5-(2-methylb...

~99%

Ethanone, 1,1-(1H-pyrrole-2,4-diyl)bis- (9CI) Structure

Ethanone, 1,1-(...

3-ACETYLPYRROLE Structure

3-ACETYLPYRROLE

Acetyl chloride Structure

Acetyl chloride

~90%

Ethanone, 1,1-(1H-pyrrole-2,4-diyl)bis- (9CI) Structure

Ethanone, 1,1-(...

N/A Structure

~75%

Ethanone, 1,1-(1H-pyrrole-2,4-diyl)bis- (9CI) Structure

Ethanone, 1,1-(...

2-Acetyl-1H-pyrrole Structure

2-Acetyl-1H-pyrrole

Acetyl chloride Structure

Acetyl chloride

~81%

Ethanone, 1,1-(1H-pyrrole-2,4-diyl)bis- (9CI) Structure

Ethanone, 1,1-(...

3-Acetyl-1-(phenylsulfonyl)pyrrole Structure

3-Acetyl-1-(phe...

~%

Ethanone, 1,1-(1H-pyrrole-2,4-diyl)bis- (9CI) Structure

Ethanone, 1,1-(...

4-(2-methylbenzo[d][1,3]dithiol-2-yl)-2-(2-methylbenzo[d][1,3]oxathiol-2-yl)-1H-pyrrole Structure

4-(2-methylbenz...

~%

Ethanone, 1,1-(1H-pyrrole-2,4-diyl)bis- (9CI) Structure

Ethanone, 1,1-(...

Pyrrole chemistry XXV: A simplified synthesis of some 3-subs...

[Xu, Ru Xun; Anderson, Hugh J.; Gogan, Niall J.; Loader, Charles E.; McDonald, Robert Tetrahedron Letters, 1981 , vol. 22, # 49 p. 4899 - 4900]