Tetrahedron

Ni-catalyzed activation of α-chloroesters: a simple method for the synthesis of α-arylesters and β-hydroxyesters

M Durandetti, C Gosmini, J Périchon

Index: Durandetti, Muriel; Gosmini, Corinne; Perichon, Jacques Tetrahedron, 2007 , vol. 63, # 5 p. 1146 - 1153

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Citation Number: 48

Abstract

Coupling reactions of α-chloroesters with aryl halides (α-arylation) or carbonyl compounds (Reformatsky) using nickel catalyst allow, under mild conditions, the preparation of various functionalized aryl propionic acid derivatives or β-hydroxyesters. In the synthesis of aryl propionic acid derivatives, the process is efficient with aryl halides bearing either electron- withdrawing or electron-donating groups.